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2.
J Correct Health Care ; 21(4): 327-34, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26377381

RESUMO

The authors investigated the second botulism outbreak to occur in a maximum security prison in Arizona within a 4-month period. Botulism was confirmed in eight men aged 20 to 35 years who reported sharing a single batch of pruno made with potatoes. Initial symptoms included blurred vision, slurred speech, muscle weakness, ptosis, and dysphagia. All patients received heptavalent botulinum antitoxin, seven required mechanical ventilation, and all survived. The median incubation period was 29 hours. Sera from all patients and leftover pruno tested positive for botulinum toxin type A. Botulism should be considered among prisoners with cranial nerve palsies and descending, symmetric flaccid paralysis. Prison-brewed alcohol, particularly when made with potatoes, can be a vehicle for botulism and is associated with outbreaks of botulism in prisons.


Assuntos
Bebidas Alcoólicas/toxicidade , Botulismo/etiologia , Prisões , Solanum tuberosum , Adulto , Arizona , Antitoxina Botulínica/uso terapêutico , Toxinas Botulínicas Tipo A/isolamento & purificação , Botulismo/fisiopatologia , Botulismo/terapia , Humanos , Masculino , Respiração Artificial
3.
J Correct Health Care ; 21(4): 335-42, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26285594

RESUMO

During July to November 2012, two botulism outbreaks (12 cases total) occurred in one all-male prison; both were associated with illicitly brewed alcohol (pruno) consumption. Inmate surveys were conducted to evaluate and develop prevention and education strategies. Qualitative surveys with open-ended questions were performed among inmates from rooms where outbreaks occurred to learn about pruno consumption. Quantitative surveys assessed knowledge gained after the outbreaks and preferred information sources. For the quantitative surveys, 250 inmates were randomly selected by bed from across the correctional facility and 164 inmates were interviewed. Only 24% of inmates reported any botulism knowledge before the outbreaks and education outreach, whereas 73% reported knowledge after the outbreaks (p < .01). Preferred information sources included handouts/fliers (52%) and the prison television channel (32%).


Assuntos
Bebidas Alcoólicas/toxicidade , Botulismo/etiologia , Conhecimentos, Atitudes e Prática em Saúde , Prisões , Solanum tuberosum , Adulto , Arizona , Antitoxina Botulínica/uso terapêutico , Toxinas Botulínicas Tipo A/isolamento & purificação , Botulismo/fisiopatologia , Botulismo/terapia , Informação de Saúde ao Consumidor , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Respiração Artificial , Fatores Socioeconômicos
4.
Clin Infect Dis ; 60(11): 1650-8, 2015 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-25697743

RESUMO

BACKGROUND: Rocky Mountain spotted fever (RMSF) has emerged as a significant cause of morbidity and mortality since 2002 on tribal lands in Arizona. The explosive nature of this outbreak and the recognition of an unexpected tick vector, Rhipicephalus sanguineus, prompted an investigation to characterize RMSF in this unique setting and compare RMSF cases to similar illnesses. METHODS: We compared medical records of 205 patients with RMSF and 175 with non-RMSF illnesses that prompted RMSF testing during 2002-2011 from 2 Indian reservations in Arizona. RESULTS: RMSF cases in Arizona occurred year-round and peaked later (July-September) than RMSF cases reported from other US regions. Cases were younger (median age, 11 years) and reported fever and rash less frequently, compared to cases from other US regions. Fever was present in 81% of cases but not significantly different from that in patients with non-RMSF illnesses. Classic laboratory abnormalities such as low sodium and platelet counts had small and subtle differences between cases and patients with non-RMSF illnesses. Imaging studies reflected the variability and complexity of the illness but proved unhelpful in clarifying the early diagnosis. CONCLUSIONS: RMSF epidemiology in this region appears different than RMSF elsewhere in the United States. No specific pattern of signs, symptoms, or laboratory findings occurred with enough frequency to consistently differentiate RMSF from other illnesses. Due to the nonspecific and variable nature of RMSF presentations, clinicians in this region should aggressively treat febrile illnesses and sepsis with doxycycline for suspected RMSF.


Assuntos
Doenças Endêmicas , Febre Maculosa das Montanhas Rochosas/epidemiologia , Febre Maculosa das Montanhas Rochosas/patologia , Adolescente , Adulto , Idoso , Animais , Antibacterianos/uso terapêutico , Arizona/epidemiologia , Criança , Pré-Escolar , Diagnóstico Diferencial , Testes Diagnósticos de Rotina , Doxiciclina/uso terapêutico , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Febre Maculosa das Montanhas Rochosas/diagnóstico , Febre Maculosa das Montanhas Rochosas/tratamento farmacológico , Adulto Jovem
5.
Clin Infect Dis ; 60(11): 1659-66, 2015 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-25697742

RESUMO

BACKGROUND: Rocky Mountain spotted fever (RMSF) is a disease that now causes significant morbidity and mortality on several American Indian reservations in Arizona. Although the disease is treatable, reported RMSF case fatality rates from this region are high (7%) compared to the rest of the nation (<1%), suggesting a need to identify clinical points for intervention. METHODS: The first 205 cases from this region were reviewed and fatal RMSF cases were compared to nonfatal cases to determine clinical risk factors for fatal outcome. RESULTS: Doxycycline was initiated significantly later in fatal cases (median, day 7) than nonfatal cases (median, day 3), although both groups of case patients presented for care early (median, day 2). Multiple factors increased the risk of doxycycline delay and fatal outcome, such as early symptoms of nausea and diarrhea, history of alcoholism or chronic lung disease, and abnormal laboratory results such as elevated liver aminotransferases. Rash, history of tick bite, thrombocytopenia, and hyponatremia were often absent at initial presentation. CONCLUSIONS: Earlier treatment with doxycycline can decrease morbidity and mortality from RMSF in this region. Recognition of risk factors associated with doxycycline delay and fatal outcome, such as early gastrointestinal symptoms and a history of alcoholism or chronic lung disease, may be useful in guiding early treatment decisions. Healthcare providers should have a low threshold for initiating doxycycline whenever treating febrile or potentially septic patients from tribal lands in Arizona, even if an alternative diagnosis seems more likely and classic findings of RMSF are absent.


Assuntos
Doenças Endêmicas , Febre Maculosa das Montanhas Rochosas/epidemiologia , Febre Maculosa das Montanhas Rochosas/patologia , Animais , Feminino , Humanos , Masculino
7.
J Pediatric Infect Dis Soc ; 3(1): 81-4, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26624909

RESUMO

An outbreak investigation identified 15 pertussis cases among 5 infants and 10 healthcare professionals at 1 hospital's neonatal intensive care unit (NICU). The cost of the outbreak to this hospital was $97 745. Heightened awareness of pertussis in NICUs is key to preventing healthcare-associated spread and minimizing outbreak-control-related costs. Bordetella pertussis is a highly communicable bacterial pathogen that causes a prolonged cough illness and is spread by respiratory droplet transmission. Infants aged ≤6 months are most susceptible to B pertussis infection and pertussis-associated complications, including pneumonia, encephalopathy, and death, and are commonly hospitalized for treatment [ 1]. Despite a universal pertussis vaccination program, 27 550 pertussis cases were reported in the United States during 2010 [ 2]. Pertussis outbreaks in healthcare settings can be challenging and costly to control [3]. On September 13, 2011 and September 15, 2011, 3 pertussis cases, including 2 confirmed by B pertussis isolation, among preterm infants discharged ≤30 days previously from a 71-bed NICU of a general hospital (NICU A) were reported by Hospital B, a large pediatric facility, to Maricopa County Department of Public Health. This report describes the outbreak, examines outbreak-associated costs and risk factors that might have contributed to healthcare-associated transmission, and provides guidance to prevent outbreaks in healthcare settings.

8.
J Public Health Manag Pract ; 20(2): 205-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-23760307

RESUMO

CONTEXT: An outbreak of gastrointestinal (GI) illness among retirement community residents was reported to the Maricopa County Department of Public Health. Online surveys can be useful for rapid investigation of disease outbreaks, especially when local health departments lack time and resources to perform telephone interviews. Online survey utility among older populations, which may lack computer access or literacy, has not been defined. OBJECTIVE: To investigate and implement prevention measures for a GI outbreak and assess the utility of an online survey among retirement community residents. DESIGN: A retrospective cohort investigation was conducted using an online survey distributed through the retirement community e-mail listserv; a follow-up telephone survey was conducted to assess computer literacy and Internet access. A case was defined as any GI illness occurring among residents during March 1-14, 2012. SETTING: A barbecue in a retirement community of 3000 residents. PARTICIPANTS: Retirement community residents. INTERVENTION: Residents were directed to discard leftover food and seek health care for symptoms. A telephone survey was conducted to assess the utility of online surveys in this population. MAIN OUTCOME MEASURES: Computer literacy and Internet access of retirement community residents. RESULTS: Of 1000 residents on the listserv, 370 (37%) completed the online survey (mean age, 69.7 years; 60.6% women); 66 residents (17.8%) reported a GI illness after the barbecue, 63 (95.5%) reported diarrhea, and 5 (7.6%) reported vomiting. Leftover beef from an attendee's refrigerator grew Clostridium perfringens. Of 552 residents contacted by telephone, 113 completed the telephone survey (mean age, 71.3 years; 63.3% women), 101 (89.4%) reported the ability to send e-mail, 82 (81.2%) checked e-mail daily, and 28 (27.7%) checked e-mail on a handheld device. The attack rate was 17.8% for online versus 2.7% for telephone respondents (P < .001). CONCLUSIONS: This outbreak demonstrated the utility of an online survey to rapidly collect information and implement prevention measures among an older demographic.


Assuntos
Infecções por Clostridium/epidemiologia , Alfabetização Digital/estatística & dados numéricos , Surtos de Doenças/estatística & dados numéricos , Correio Eletrônico/estatística & dados numéricos , Doenças Transmitidas por Alimentos/epidemiologia , Gastroenteropatias/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Arizona/epidemiologia , Infecções por Clostridium/etiologia , Infecções por Clostridium/microbiologia , Clostridium perfringens/isolamento & purificação , Clostridium perfringens/patogenicidade , Coleta de Dados , Métodos Epidemiológicos , Feminino , Doenças Transmitidas por Alimentos/etiologia , Doenças Transmitidas por Alimentos/microbiologia , Gastroenteropatias/etiologia , Gastroenteropatias/microbiologia , Habitação para Idosos/estatística & dados numéricos , Humanos , Internet/estatística & dados numéricos , Masculino , Aposentadoria , Estudos Retrospectivos , Telefone/estatística & dados numéricos
9.
J Med Case Rep ; 7: 190, 2013 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-23890272

RESUMO

INTRODUCTION: We report the seventh case of Chryseobacterium indologenes occurring in the United States of America. C. indologenes is seldom isolated from clinical specimens but has caused hospital-acquired infections in Taiwan and rarely elsewhere. CASE PRESENTATION: A 32-year-old Caucasian woman with metastatic breast cancer presented to a hospital emergency department with bilateral radiation-induced pleural effusions and respiratory failure. The patient was hospitalized and ventilated for 26 days; tracheal aspirates collected on ventilation days 24 and 26 grew C. indologenes. The patient subsequently died as a result of worsening ventilator-associated pneumonia and stage IV breast cancer. CONCLUSIONS: C. indologenes infection should be considered for hospitalized patients with a history of malignancy, especially those with indwelling devices and antibiotic use for >14 days.

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