[THE EFFECTIVENESS OF DIAGNOSIS AND TREATMENT OF CEREBROVASCULAR DISORDERS IN HYPERTENSIVE ENCEPHALOPATHY IN ELDERLY PATIENTS BY STUDYING THE CHARACTERISTICS OF CEREBRAL HEMODYNAMICS AND CEREBRAL PERFUSION STATUS].

Intrigue progression of hypertensive encephalopathy (HE) in older patients is that the development of cognitive impairment and high blood pressure underestimated, aslo exist without clinical manifestations. In recent decades convincing proved that the basis for the development of various diseases is cerebral dysfunction systems regulating brain blood flow, including--autoregulation system, which largely affects the blood supply to the brain. This explains the fact that patients with chronic brain ischemia cerebral hemodynamic status largely depends on the condition and stability of the regulatory mechanisms of systemic and cerebral hemodynamics, particularly of systemic blood pressure, regional cerebral blood supply, normalization which, in the early stages of development disorders, prevents of serious complications. In this paper the theoretical generalization and new solution of scientific and practical problems of hypertension influence on the formation of chronic cerebral ischemia in elderly patients on a background of hypertension--specified risk factors and especially the formation of a comprehensive study on the basis of clinical and neurological data, tool sand methods for neuroimaging research developed and improved methods of diagnosis. Found that in elderly patients with HE and HBP observed significant (P < 0.05) increase in the thickness of the intima-media complex was significantly higher (dextra--1.12 ± 0.03 and sinistra--1.11 ± 0.03), than middle-aged patients with hypertension at HE, which constitutes a violation of the elastic properties of the vascular wall. Established correlation data radionuclide study ultrasonic duplex scanning of vessels of the head and neck. A negative correlation of intima-media and severity of lesions according to hypoperfusion of computer tomography single photon emission (r = -0.49; P < 0.05); confirming the progression of HE in elderly patients needs improvement and treatment.

Clinical evaluation of a method of quantitative determination of homovanillic acid for the estimation of degree of tumor dissemination process in melanoma of the skin.

Homovanillic acid (HVA) was determined both in 45 patients with different forms of melanoma and those hospitalized on the suspicion of melanoma and in 15 healthy persons. Excretion rate of homovanillic acid within the normal limits was observed in patients with benign melanotic neoplasms of the skin (4.4 +/- 0.56 mg/24 hr) and in local forms of melanotic melanoma of the skin (4.5 +/- 0.24 mg/24 hr). In patients with metastases to regional nodes as well as in patients with locally disseminated forms of melanotic melanoma of the skin the concentration of homovanillic acid increased up to 11.1 +/- 0.93 mg/24 hr. Especially strong concentration of homovanillic acid was registered in patients with disseminated malanotic melanoma of the skin, and it made up 15.7 +/- 2.04 mg/24 hr. There was evident tendency to the elevation of HVA excretion level as generalization of the process which was taking place. The data obtained enable the authors to recommend the determination of HVA excretion as an additional diagnostic test as well for prognosis of melanoma development together with other clinicomorphological data.