Enhancing Lung Cancer Survival Prediction: 3D CNN Analysis of CT Images Using Novel GTV1-SliceNum Feature and PEN-BCE Loss Function.

Lung cancer is a prevalent malignancy associated with a high mortality rate, with a 5-year relative survival rate of 23%. Traditional survival analysis methods, reliant on clinician judgment, may lack accuracy due to their subjective nature. Consequently, there is growing interest in leveraging AI-based systems for survival analysis using clinical data and medical imaging. The purpose of this study is to improve survival classification for lung cancer patients by utilizing a 3D-CNN architecture (ResNet-34) applied to CT images from the NSCLC-Radiomics dataset. Through comprehensive ablation studies, we evaluate the effectiveness of different features and methodologies in classification performance. Key contributions include the introduction of a novel feature (GTV1-SliceNum), the proposal of a novel loss function (PEN-BCE) accounting for false negatives and false positives, and the showcasing of their efficacy in classification. Experimental work demonstrates results surpassing those of the existing literature, achieving a classification accuracy of 0.7434 and an ROC-AUC of 0.7768. The conclusions of this research indicate that the AI-driven approach significantly improves survival prediction for lung cancer patients, highlighting its potential for enhancing personalized treatment strategies and prognostic modeling.

Calcific pulmonary nodule, is it wandering?

Wandering pulmonary nodule is defined as a nodule with morphologically identical features found in different regions of the lung on different imaging studies. In this article, we report a 61-year-old patient who was examined for cough and found to have an 8 mm calcific nodule in the lower lobe of the left lung on computed tomography (CT) scan (Fig. 1A, B). On follow-up CT scan two years later, a nodule with the same morphology and size was detected in the same lobe but at a different location (Fig. 1C, D).

Bibliometric analysis of 40 most cited articles comparing video-assisted thoracic surgery and robotic-assisted thoracic surgery in lung cancer (1997-2021).

Background: In recent years, conventional thoracoscopic surgery has been accepted as the traditional treatment method in the non-small cell lung cancer (NSCLC). VATS and RATS, which are the techniques of this surgical method, have been increasing their effectiveness and applicability of late years. The aim of this bibliometric analysis is to evaluate the importance and efficiency of articles comparing VATS and RATS techniques. Materials and methods: Studies comparing VATS and RATS published between 1997 and 2021 were identified in the Web of Science database (accessed on 31. 12. 2021). The 40 most cited studies were analyzed in terms of publication years, country of study, authors, institutions that the authors were affiliated with, journal, journal address and impact factor. Results: While an article was cited a maximum of 187 times when the citations made by the authors were excluded from the analysis, it was observed that all publications were cited a total of 1946 times. It was seen that an average of 51. 30 ± 47. 73 (8-187) articles were cited. In the 25-year, the highest number of publications was reached in 2019, while eight articles were published this year. The Annals of Thoracic Surgery (n = 13, 32. 5 %) was the journal in which the articles in the list were published the most. Most of the articles in our study (n = 31, 77.5 %) were published in US journals. While many studies presented more than one topic and analysis, the topic of most interest in 19 (47.5 %) studies was postoperative complications. Conclusion: This bibliometric analysis reflects important and qualified articles comparing VATS and RATS technique in thoracic surgery, but it can also be used to explain or explain the performance and results of these techniques, their positive and negative aspects, and their superiority over each other.

Pleural angiosarcoma presenting with spontaneous hemothorax.

Angiosarcomas (ASs) are very rare and constitute 1-2% of soft tissue malignancies. Primary pleural AS (PPAS) is a very rare neoplasm, with only 50 cases reported in the literatüre, and is a tumor with a high tendency for local recurrence and metastasis, with an aggressive course and a generally poor prognosis unless diagnosed early. It originates from the endothelial cells of small blood vessels and therefore can affect many organs. The etiology and definitive method in the treatment is still unclear. Patients usually present with nonspecific symptoms such as cough, dyspnea, chest pain, and hemoptysis. Recurrent exudative or hemorrhagic pleural effusion may develop due to its pleural location. The diagnosis can be made by histopathological and immunohistochemical examinations of excisional biopsy specimens. The effectiveness of chemotherapy and radiotherapy is weak and can be applied for palliative purposes. Surgical approach can be used for diagnostic and palliative purposes. Due to the high degree of malignancy and insidious course of PPAS, patients usually die within months after diagnosis. In these patients, surgical exploration is important for the diagnosis and palliative/definitive treatment of the disease. We present a 61-year-old male patient who presented with dyspnea, chest pain, and massive pleural effusion findings in the left hemithorax and was diagnosed with PPAS as a result of pleural biopsy.

The Scalable Fuzzy Inference-Based Ensemble Method for Sentiment Analysis.

Internet environments such as social networks, news sites, and blogs are the platforms where people can share their ideas and opinions. Many people share their comments instantly on the internet, which results in creating large volumes of entries. It is important for institutions and organizations to analyze this big data in an efficient and rapid manner to produce summary information about the feelings or opinions of individuals. In this study, we propose a scalable framework that makes sentiment classification by evaluating the compound probability scores of the most widely used methods in sentiment analysis through a fuzzy inference mechanism in an ensemble manner. The designed fuzzy inference system makes the sentiment estimation by evaluating the compound scores of valance aware dictionary, word embedding, and count vectorization processes. The difference of the proposed method from the classical ensemble methods is that it allows weighting of base learners and combines the strengths of each algorithm through fuzzy rules. The sentiment estimation process from text data can be managed either as a 2-class (positive and negative) or as a 3-class (positive, neutral, and negative) problem. We performed the experimental work on four available tagged social network data sets for both 2-class and 3-class classifications and observed that the proposed method provides improvements in accuracy.

Comparison of Anxiety and Narcissism Levels of Different Performance Groups in Female Handball Players.

Objective: This study aimed to compare the anxiety and narcissism levels of different performance groups in female handball players. Methods: A total of 59 athletes between the ages of 15 and 37 participated in the study, taking the first 4 places from the Turkish Republic of Northern Cyprus senior women handball 1st league in the 2017-2018 season. Wingate peak power (WPP), Wingate average power (WAP), handball agility test (HAST), 10 m speed (10S), 20 m speed (20S), 20m shuttle run (SR), hands on waist vertical jump (HEVJ), hands free vertical jumping (HFVJ) test, Beck anxiety scale (BAI), 5-factor narcissism scale-short form (FFNI-SF), and sociodemographic data form were used. The athletes were divided into upper performance (UPG) and lower performance groups (LPG) using the median value according to the results of the physical measurement tests (FST). Results: It was determined that the anxiety level of the participants in the LPG group was higher than that in the UPG group. The narcissism level of the participants in the UPG group was found to be higher than that in the LPG group. The scores of consent seeking, arrogance, leader/authority, insecurity, claiming rights, exhibitionism, carelessness, lack of empathy, and adventurousness were higher than LPG. In the correlation analysis, a positive and low level of relationship between anxiety and 20S and a negative and low level of significant relationship between HEJV were found. It was observed that there was a positive and low level significant relationship between narcissism and WPP, HFJV, and HEJV. It has been revealed that anxiety and narcissism variables have a predictive effect on the physical performance average score. Conclusion: The findings suggest that in female handball players, high levels of narcissism may affect the performance positively and high anxiety levels negatively. As a result of this study, it was revealed that anxiety and narcissism have a predictive effect on physical performance average score in women's handball.

Kinematic and Electromyographic Activity Changes during Back Squat with Submaximal and Maximal Loading.

The aim of this study was to investigate the possible kinematic and muscular activity changes with maximal loading during squat maneuver. Fourteen healthy male individuals, who were experienced at performing squats, participated in this study. Each subject performed squats with 80%, 90%, and 100% of the previously established 1 repetition maximum (1RM). Electromyographic (EMG) activities were measured for the vastus lateralis, vastus medialis, rectus femoris, semitendinosus, biceps femoris, gluteus maximus, and erector spinae by using an 8-channel dual-mode portable EMG and physiological signal data acquisition system (Myomonitor IV, Delsys Inc., Boston, MA, USA). Kinematical data were analyzed by using saSuite 2D kinematical analysis program. Data were analyzed with repeated measures analysis of variance (p < 0.05). Overall muscle activities increased with increasing loads, but significant increases were seen only for vastus medialis and gluteus maximus during 90% and 100% of 1RM compared to 80% while there was no significant difference between 90% and 100% for any muscle. The movement pattern in the hip joint changed with an increase in forward lean during maximal loading. Results may suggest that maximal loading during squat may not be necessary for focusing on knee extensor improvement and may increase the lumbar injury risk.

Kinematic and EMG activities during front and back squat variations in maximum loads.

The aim of this study was to compare the musculature activity and kinematics of knee and hip joints during front and back squat with maximal loading. Two-dimensional kinematical data were collected and electromyographic activities of vastus lateralis, vastus medialis, rectus femoris, semitendinosus, biceps femoris, gluteus maximus and erector spinae were measured while participants (n = 12, 21.2 ± 1.9 years old) were completing front and back squat exercises with maximum loading. Paired sample t-test was used for comparisons between two techniques. Results showed that the electromyographic activity of vastus medialis was found to be greater in the front squat compared to the back squat during the ascending phase (P < 0.05, d = 0.62; 95% CI, -15.0/-4.17) and the whole manoeuvre (P < 0.05, d = 0.41; 95% CI, -12.8/-0.43), while semitendinosus (P < 0.05, d = -0.79; 95% CI, 0.62/20.59) electromyographic activity was greater in the back squat during the ascending phase. Compared to the front squat version, back squat exhibited significantly greater trunk lean, with no differences occurring in the knee joint kinematics throughout the movement. Results may suggest that the front squat may be preferred to the back squat for knee extensor development and for preventing possible lumbar injuries during maximum loading.

Impact of ligating gonadal or adrenal collateral veins with the left renal vein on renal function and histology in right-nephrectomized rats.

BACKGROUND: In cases of trauma to the left renal vein (LRV), its ligation near the inferior vena cava (IVC) is considered, but the consequences are not always good. We investigated the role of collateral venous drainage after ligation of the LRV by studying the renal function and histology after ligation of the LRV near the IVC alone or with ligation of the gonadal or adrenal collaterals, in right-nephrectomized (RN) rats. MATERIAL AND METHODS: Ligation of the LRV near the IVC alone (group 1) or with ligation of the adrenal (group 2) or gonadal (group 3) collaterals was studied in RN Wistar rats (n=18 per group). The renal histopathology (ischemic cortical necrosis) and functional status (urea, creatinine, sodium, and potassium) were compared. RESULTS: In RN rats, the results were better when ligating the LRV near the IVC alone or with the adrenal collaterals [mortality 4/18 (22.2%) and 3/18 (16.7%), respectively] than when ligating the LRV near the IVC plus the gonadal collaterals [mortality 15/18 (83.3%)] (p<0.0001). All early deaths occurred within three days and resulted from serious histopathological (ischemic cortical necrosis) and functional (increased urea, creatinine, and potassium; decreased sodium) renal damage. CONCLUSION: In right-nephrectomized rats, the LRV near the IVC and the adrenal collateral can be ligated, while the gonadal collateral should be preserved.

Type 1 gastric carcinoid tumor: another extrahepatic manifestation of hepatitis C virus infection?

A 67 year-old female with a 10-year history of cirrhosis due to hepatitis C virus who developed a gastric carcinoid tumor of the corpus is described. Carcinoid tumor was identified during her last routine gastroscopic evaluation for portal hypertension. In the case, serum parietal cell antibodies, hypergastrinemia and atrophic gastritis were also found. Chronic hepatitis C virus infection is known to induce clinical and laboratory signs of autoimmunity. But the question of whether hepatitis C virus plays a pathogenic role in the development of gastric carcinoid tumor is unknown. As far as we know, this is the first report describing gastric carcinoid tumor in hepatitis C virus induced chronic liver disease. We suggest that the possibility of the development of autoimmune atrophic gastritis and carcinoid tumors should be considered in patients with chronic hepatitis C that coexists with autoimmune diseases and has positive parietal cell antibodies.