RESUMO
The competition between the native and the grafted liver in heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) was investigated in a rat model. The experimental groups were: HALT with flow-regulated PVA and 70% resection of a native liver and graft (n = 32; group I) versus 70% liver resection (n = 32; group II). After HALT, the weight of the native liver increased until the sixth postoperative week (431% +/- 55% of the intraoperative weight), whereas, the graft weight was only 76% +/- 31% of the intraoperative weight at this time. In group II, liver weight increased continuously to 529% +/- 30% of the intraoperative weight after 6 weeks. On postoperative day 2, there was significantly increased proliferative hepatocellular activity in all groups. This was highest in the resected livers of group II, followed by the native livers of group I, and the grafts of group I (301 +/- 126 vs 262 +/- 97 vs 216 +/- 31 Ki-67-positive hepatocytes/10 visual fields). However, the differences between the groups were not significant. With regard to hepatocellular apoptosis, the livers were similar among all groups and at all time points, M30-positive hepatocyte counts were Assuntos
Transplante de Fígado/fisiologia
, Fígado/fisiologia
, Animais
, Compostos de Diazônio/farmacocinética
, Farneseno Álcool/análogos & derivados
, Farneseno Álcool/farmacocinética
, Rejeição de Enxerto/fisiopatologia
, Antígeno Ki-67/análise
, Testes de Função Hepática
, Masculino
, Modelos Animais
, Tamanho do Órgão
, Veia Porta/fisiologia
, Ratos
, Tecnécio/farmacocinética
RESUMO
We report a case of an isolated atherosclerotic true aneurysm of the profunda femoris artery. The aneurysm was surgically ligated. The clinical presentation, diagnostic algorithm and therapeutic options are discussed in the scope of the English-language literature.