Core point pixel-level localization by fingerprint features in spatial domain.

Singular point detection is a primary step in fingerprint recognition, especially for fingerprint alignment and classification. But in present there are still some problems and challenges such as more false-positive singular points or inaccurate reference point localization. This paper proposes an accurate core point localization method based on spatial domain features of fingerprint images from a completely different viewpoint to improve the fingerprint core point displacement problem of singular point detection. The method first defines new fingerprint features, called furcation and confluence, to represent specific ridge/valley distribution in a core point area, and uses them to extract the innermost Curve of ridges. The summit of this Curve is regarded as the localization result. Furthermore, an approach for removing false Furcation and Confluence based on their correlations is developed to enhance the method robustness. Experimental results show that the proposed method achieves satisfactory core localization accuracy in a large number of samples.

Open set recognition algorithm based on Conditional Gaussian Encoder.

For the existing Closed Set Recognition (CSR) methods mistakenly identify unknown jamming signals as a known class, a Conditional Gaussian Encoder (CG-Encoder) for 1-dimensional signal Open Set Recognition (OSR) is designed. The network retains the original form of the signal as much as possible and deep neural network is used to extract useful information. CG-Encoder adopts residual network structure and a new Kullback-Leibler (KL) divergence is defined. In the training phase, the known classes are approximated to different Gaussian distributions in the latent space and the discrimination between classes is increased to improve the recognition performance of the known classes. In the testing phase, a specific and effective OSR algorithm flow is designed. Simulation experiments are carried out on 9 jamming types. The results show that the CSR and OSR performance of CG-Encoder is better than that of the other three kinds of network structures. When the openness is the maximum, the open set average accuracy of CG-Encoder is more than 70%, which is about 30% higher than the worst algorithm, and about 20% higher than the better one. When the openness is the minimum, the average accuracy of OSR is more than 95%.

Preparation, characterization and in vitro and in vivo evaluation of a solid dispersion of Naringin.

Naringin (NA) is one of typical flavanone glycosides widely distributed in nature and possesses several biological activities including antioxidant, anti-inflammatory, and antiapoptotic. The aim of this study was to develop solid dispersion (SD) and to improve the dissolution rate and oral bioavailability of NA. NA-SD was prepared by the traditional preparation methods using PEG6000, F68, or PVP K30 as carrier at different drug to carrier ratios. According to the results of solubility and in vitro dissolution test, the NA-PEG6000 (1:3) SD was considered as an optimal formulation to characterize by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry and powder X-ray diffraction. Furthermore, oral bioavailabilities of NA-PEG6000 (1:3) SD and NA-suspension with the same dosage were investigated in SD rats. The results confirmed the formation of SD and the pharmacokinetic parameters of NA-PEG6000 (1:3) SD (Cmax = 0.645 ± 0.262 µg/ml, AUC0-t = 0.471 ± 0.084 µg/ml h) were higher than that of NA-suspension (Cmax = 0.328 ± 0.183 µg/ml, AUC0-t = 0.361 ± 0.093 µg/ml h). Based on the results, the SD is considered as a promising approach to enhance the dissolution rate and oral bioavailability of NA.

[The effect of morin on activation, proliferation and cell-cycle of murine T lymphocytes in vitro].

AIM: To discover the effects of morin on the activation, proliferation and cell-cycle of murine T lymphocytes in vitro. METHODS: Murine lymph node-derived T lymphocytes were separated and stimulated with concanavalin A (ConA) and different experimental groups were set by co-cultured with morin of different final concentration. Flow cytometry (FCM) was used to detect the activation, proliferation [carboxylfluorescein diacetate, succinimide ester (CFDA-SE) staining] and cell-cycle [propidium iodide(PI) staining] of T cells. RESULTS: After 6 h time of culture in vitro, the rate of CD69(+) T cells in control group was (2.97+/-0.12)%, while it was significant higher in ConA group [(72.52+/-0.66)% (P<0.01)]. Morin could down-regulate this rate at final concentration being 25, 50 and 100 micromol/L, with a peak at 100 micromol/L morin [(48.95+/-0.81)% (P<0.01)]. CFDA-SE staining showed that at 48 h and 72 h, the proliferation indexes (PI) of T cells in ConA group were (1.58+/-0.04) and (1.95+/-0.02), respectively. Morin could significantly decrease the PI value at all experimental concentration, with the peak effect at 100 micromol/L morin, which the PI for 48 h was (1.02+/-0.02) and (1.03+/-0.01) for 72 h (P<0.01). FCM analysis of PI staining implied that the percentage of S phase cells in ConA group was (27.05+/-0.39)%, significantly higher than that in control group (5.10+/-0.07)%; and the 25 and 50 micromol/L morin groups showed higher S phase cell rates. CONCLUSION: Morin can significantly inhibit ConA stimulated activation and proliferation of murine T lymphocytes, in which the S phase lagging may serve as one of the major mechanisms.