Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies.

Background: The effects of conduction system pacing (CSP) compared with conventional biventricular pacing (BVP) on heart function in patients with heart failure remain elusive. Methods: PubMed, Embase, Cochrane's Library and Web of science databases were searched up to 1 October 2022 for pertinent controlled studies. Random or fixed-effect model were used to synthesize the clinical outcomes. Subgroup analysis was performed to screen the potential confounding factors. Results: Fifteen studies including 1,347 patients were enrolled. Compared with BVP, CSP was significantly associated with shortened QRS duration [WMD -22.51 ms; p = 0.000], improved left ventricular ejection fraction [WMD 5.53%; p = 0.000], improved NYHA grade [WMD -0.42; p = 0.000], higher response rate and lower heart failure rehospitalization rate. CSP resulted in better clinical outcomes in higher male proportion group than lower one compared with BVP. No significant differences of clinical outcomes were observed between left bundle branch area pacing (LBBaP) and his bundle pacing (HBP) except the pacing threshold. The pacing threshold of LBBaP was significantly lower than those in BVP and HBP. Conclusion: This study suggests that CSP might be superior to conventional BVP for HF patients. In a higher male proportion group, CSP may be associated with more benefits than BVP. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355991; Identifier: CRD42022355991.

Pollution characteristics and ecological risk of microplastic in sediments of Liaodong Bay from the northern Bohai Sea in China.

Microplastics (MPs) are widely distributed in marine environments. The pollution characteristics and risk assessment of MPs in estuarine sediments are still insufficient. In this study, the MPs pollution characteristics in surface sediments of the Liao Estuary and Daliao Estuary were investigated. The characteristics of MPs in sediments were determined by stereo microscopy and micro-Fourier transform infrared spectroscopy. The results showed that the average MPs abundance ranged from 32.33 to 49.91 items·kg-1 d.w. The MPs were mainly composed of 500-2000 µm black and blue fibers. Five polymer types were identified, including rayon (RA) (87.46 %), polyethylene terephthalate (PET) (6.81 %), polyamide (PA) (2.94 %), polypropylene (PP) (2.17 %) and polyethylene (PE) (0.62 %). The pollution load index (PLI) risk assessment showed that all sampling sites were at Hazard Level I. Our results can provide useful information for assessing the environmental risks of MPs in coastal areas of China.

Characteristics and spatiotemporal distribution of microplastics in sediments from a typical mariculture pond area in Qingduizi Bay, North Yellow Sea, China.

Microplastics (MPs) in mariculture environments may have an impact on mariculture and ecosystems. This study sampled the sediments in mariculture ponds and offshore areas in Qingduizi Bay during winter and summer. The abundance, characteristics, spatiotemporal distribution and pollution risk of microplastics were analyzed. The results showed that the abundance of MPs in the mariculture pond and offshore area was 49.2 ± 35.9 items·kg-1 d.w. and 17.1 ± 9.9 items·kg-1 d.w.; the MPs were mainly composed of transparent fibers of thickness 2000-5000 µm, with the main polymers being polyethylene terephthalate (PET) and cellophane (CP). The spatial distribution showed a downward trend from the inside to the outside, but the difference was not significant when comparing different seasons. The pollution load index (PLI) risk assessment showed that all sampling sites were at Hazard Level I. This study can provide valuable information for the risk assessment of microplastic pollution in mariculture areas.

On the degradation of (micro)plastics: Degradation methods, influencing factors, environmental impacts.

Plastics and microplastics are difficult to degrade in the natural environment due to their hydrophobicity, the presence of stable covalent bonds and functional groups that are not susceptible to attack. In nature, microplastics are more likely to attract other substances due to their large specific surface area, which further prevents degradation from occurring. Some of these substances are toxic and harmful, and can be spread to various organisms through the food chain along with the microplastics to cause harm to them. Degradation is an effective way to eliminate plastic pollution, and a comprehensive understanding of the methods and mechanisms of plastic degradation is necessary, because it is the result of synergistic effects of several degradation methods, both in nature and in consideration of future engineering applications. The authors firstly summarize the degradation methods of (micro)plastics; secondly, review the influence of intrinsic properties and environmental factors during the degradation process; finally, discuss the environmental impact of the degradation products of (micro)plastics. It is evident that the degradation of (micro)plastics still has many challenges to overcome, and there are no mature and effective methods that can be applied in engineering practice or widely used in nature. Therefore, there is an urgent need for research on the degradation of (micro)plastics.