Synthesis of a 2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate building block and a model dinucleotide.

In order to obtain higher quality 2'-O-carbamoylmethyl oligoribonucleotides we are conducting studies of this modification. Here we present synthesis of 2'-O-carbamoylmethyl containing H-phosphonate building blocks as well as synthesis of model dinucleotides needed for these studies.