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1.
ACS Appl Mater Interfaces ; 16(24): 31851-31863, 2024 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-38835324

RESUMO

Different types of solvents, aromatic and aliphatic, are used in many industrial sectors, and long-term exposure to these solvents can lead to many occupational diseases. Therefore, it is of great importance to detect volatile organic compounds (VOCs) using economic and ergonomic techniques. In this study, two macromolecules based on pillar[5]arene, named P[5]-1 and P[5]-2, were synthesized and applied to the detection of six different environmentally volatile pollutants in industry and laboratories. The thin films of the synthesized macrocycles were coated by using the spin coating technique on a suitable substrate under optimum conditions. All compounds and the prepared thin film surfaces were characterized by NMR, Fourier transform infrared (FT-IR), elemental analysis, atomic force microscopy (AFM), scanning electron microscopy (SEM), and contact angle measurements. All vapor sensing measurements were performed via the surface plasmon resonance (SPR) optical technique, and the responses of the P[5]-1 and P[5]-2 thin-film sensors were calculated with ΔI/Io × 100. The responses of the P[5]-1 and P[5]-2 thin-film sensors to dichloromethane vapor were determined to be 7.17 and 4.11, respectively, while the responses to chloroform vapor were calculated to be 5.24 and 2.8, respectively. As a result, these thin-film sensors showed a higher response to dichloromethane and chloroform vapors than to other harmful vapors. The SPR kinetic data for vapors validated that a nonlinear autoregressive neural network was performed with exogenous input for the best molecular modeling by using normalized reflected light intensity values. It can be clearly seen from the correlation coefficient values that the nonlinear autoregressive with exogenous input artificial neural network (NARX-ANN) model for dichloromethane converged more successfully to the experimental data compared to other gases. The correlation coefficient values of the dichloromethane modeling results were approximately 0.99 and 0.98 for P[5]-1 and P[5]-2 thin-film sensors, respectively.

2.
Front Psychol ; 14: 1260480, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38022978

RESUMO

Introduction: Trust is essential for establishing stable and fulfilling romantic relationships between partners. Development of trust, however, can be assumed to depend on many factors related to an individual's earlier experiences and relationship-related beliefs. This study aimed to investigate how adult attachment style (anxious, avoidant), experiences about parents' divorce and breakdown of one's own romantic relationship, and relationship beliefs are related to the level of dyadic trust in romantic relationships. Methods: The present study included 131 Turkish undergraduate university students (55.7% women) from different faculties. The research instrument had questions about parents' and respondents' own relationship status, Dyadic Trust Scale (DTS), Experiences in Close Relationships Inventory-Revised (ECR-R), and Inventory of Close Relationship Beliefs (ICRB), in addition to background questions. The data were analyzed using descriptive statistics, t-tests, Pearson correlations, regression analyses and mediation analyses. Results: Respondents whose parents had divorced or who had experienced a relationship breakdown had lower dyadic trust scores than those without these experiences. The trust scores correlated negatively with anxious and avoidant attachment styles and positively with relationship belief scales, although the correlations to "external factors" were not statistically significant. In regression analysis, anxious and avoidant attachment styles explained 42% and relationship beliefs 25% of the variance in trust. The only significant predictor among beliefs was "individuality." Mediation analysis showed that the effects of anxious attachment style on trust were fully mediated by the relationship belief in "individuality." The avoidant attachment style had a direct relationship to trust. Discussion: The results show that anxious attachment style influences trust via relationship beliefs, while avoidant attachment style has a strong direct effect on trust as well as weaker effects via beliefs. The results are discussed in the context of Turkish culture and horizontal collectivism.

3.
Hormones (Athens) ; 18(2): 237-240, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30778850

RESUMO

There are numerous causes, such as environmental factors, medications, endocrine disorders, and genetic factors, that can lead to obesity. However, severe early-onset obesity with abnormal feeding behavior, mental retardation, dysmorphic features, organ-specific developmental abnormalities, and endocrine disorders suggest a genetic etiology. Mutations in genes related to the leptin-melanocortin pathway play a key role in genetic obesity. This pathway controls hypothalamic regulation of food intake. A few cases have been reported to have mutations in leptin (LEP) or leptin receptor (LEPR) genes. The cases had severe early-onset obesity, hyperphagia, and additional features, such as altered immune function, hypogonadism, and hypothyroidism. We present a 3-year-old male patient with severe early-onset obesity whose genetic analysis revealed a homozygous, novel, and pathogenic variant (c.1603+2T>C) in LEPR.


Assuntos
Mutação , Obesidade Mórbida/genética , Obesidade Infantil/genética , Receptores para Leptina/genética , Análise Mutacional de DNA , Homozigoto , Humanos , Hiperfagia/complicações , Hiperfagia/diagnóstico , Hiperfagia/genética , Lactente , Masculino , Obesidade Mórbida/diagnóstico , Obesidade Mórbida/patologia , Obesidade Infantil/diagnóstico , Obesidade Infantil/patologia , Linhagem
5.
J Paediatr Child Health ; 43(3): 191-2, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17316197

RESUMO

An 11-month-old Turkish boy was hospitalised with clinical and roentgen graphic evidence of large pleural effusion on the third day of fever and misdiagnosed as parapneumonic effusion. Due to worsening respiratory distress chest tube drainage was performed. Four days later the classic signs of Kawasaki disease appeared. His clinical condition improved gradually and fever subsided after intravenous gammaglobulin and aspirin treatment. A mild transient dilatation of the right coronary artery was seen and returned to the normal diameter within a few weeks. To our knowledge, large pleural effusion in a case of Kawasaki disease, in which chest tube drainage was needed, has not been reported. We describe here a patient with complete Kawasaki disease whose initial presentation mimicked a parapneumonic effusion.


Assuntos
Tubos Torácicos , Drenagem , Síndrome de Linfonodos Mucocutâneos , Derrame Pleural , Criança , Humanos , Masculino , Síndrome de Linfonodos Mucocutâneos/complicações , Derrame Pleural/terapia , Insuficiência Respiratória
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