A new meroterpenoid tatenoic acid from the fungus Neosartorya tatenoi KKU-2NK23.

A new meroterpenoid, named tatenoic acid (1), was isolated from the fungus Neosartorya tatenoi KKU-2NK23, together with five known compounds, aszonapyrones A and B (2 and 3), aszonalenin (4), ergosterol (5) and D-mannitol (6). Their structures were established on the basis of spectroscopic methods. Aszonapyrones A (2) exhibited antimalarial activity against Plasmodium falciparum, and it also exhibited cytotoxicity against two cancer cell lines, NCI-H187 and KB.