Zero contrast optical coherence tomography-guided percutaneous coronary intervention in patients with non-ST segment elevation myocardial infarction and chronic kidney disease.

OBJECTIVES: To investigate a strategy for ultra-low volume contrast percutaneous coronary intervention (PCI) with the aims of preserving renal function and observing the 90-day clinical endpoint in patients with non-ST-elevated myocardial infarction (non-STEMI) and chronic kidney disease (CKD). BACKGROUND: The feasibility, safety, and clinical utility of PCI with ultra-low radio-contrast medium in patients with non-STEMI and CKD are unknown. METHODS: A total of 29 patients with non-STEMI and CKD (estimated glomerular filtration rate [eGFR] of ≤60 ml/min/1.73 m2 ) were included. Ultra-low volume contrast PCI was performed after minimal contrast coronary angiography using zero contrast optical coherence tomography (OCT) guidance. Pre- and post-PCI angiographic measurements were performed using quantitative flow ratio (QFR) for pre-perfusion assessment and verifying improvement. RESULTS: The median creatinine level was 2.1 (inter-quartile range 1.8-3.3), and mean eGFR was 48 ± 8 ml/min/1.73 m2 pre-PCI. During the PCI procedure, OCT revealed 15 (52%) cases of abnormalities post-dilation. There was no significant change in the creatinine level and eGFR in the short- or long-term, and no major adverse events were observed. CONCLUSION: In non-STEMI patients with high-risk CKD who require revascularization, QFR and no contrast OCT-guided ultra-low contrast PCI may be performed safely without major adverse events.

Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.

Lipid accumulation in nonadipose tissues is increasingly linked to the development of type 2 diabetes in obese individuals. We report here the design, synthesis, and evaluation of a series of novel PPARalpha selective activators containing 1,3-dicarbonyl moieties. Structure-activity relationship studies led to the identification of PPARalpha selective activators (compounds 10, 14, 17, 18, and 21) with stronger potency and efficacy to activate PPARalpha over PPARgamma and PPARdelta. Experiments in vivo showed that compounds 10, 14, and 17 had blood glucose lowering effect in diabetic db/db mouse model after two weeks oral dosing. The data strongly support further testing of these lead compounds in other relevant disease animal models to evaluate their potential therapeutic benefits.

Preliminary approach to estimation and prediction of infrared spectroscopy for Mannich bases by atomic electronegativity distance vector (VAED).

Systematical studies were made on infrared spectroscopy (IR) and its regularity of vibration frequency. By applying a novel molecular structural descriptor vector containing four elements, called atomic electronegativity (EN) distance vector (VAED) expressed in the form of force, to characterize the chemical environment of various atoms in Mannich bases, the quantitative relationship models of IR of Mannich bases were established with respect to their VAED descriptors, based on multiple linear regression (MLR) analysis. In order to demonstrate the modeling stabilities and predictive abilities of diverse models, a cross validation (CV) with the leave-one-out (LOO) procedure was performed for each modeling equation. For the first panel of the 17 examined analogous Mannich bases, the correlation coefficient (R) between the observed and estimated vibration frequencies and standard deviation (S.D.) both for the double covalent bonds, C, O ami Pz.sbnd;O are 0.9782, 0.9817, 9.1170 and 11.0649; and the corresponding R and S.D. obtained by the CV method are 0.9496, 0.8829, 14.1186 and 27.2829, respectively, which shows that the quantitative structure-spectrum relationship (QSSR) models are quite stable and have both good estimative results and fine predictive capabilities. For the second panel of the 16 examined Mannich bases, the results still seem satisfied since the QSSR model is stable and could roughly estimate and predict the vibration frequency of the Cz.dbnd6;O bond for the other related Mannich bases.