Comparison on the preparation of rat models of pneumonia by different infection route / 中国实验动物学报

Objective To explore the preparation of a rat model of pneumonia model induced by Pseudomonas aeruginosa( PA) using different methods,and to lay the foundation for further studies. Methods 48 SD rats were randomly divided into 4 groups:the control group (A), the intratracheal injection group (B), the trachea cannulation group (C) and the intranasal inoculation group ( D) . After intervention with different treatment modalities, the body weight,tempera-ture,white blood cell count and lung pathological changes in the rats of all groups were detected at 5, 10, 15 days. Results 1. The behavior, body weight, temperature, leukocytes and pathological inflammatory changes of the lung in rats of the model groups were significantly different from that of control group. 2. Pseudomonas aeruginosa was detected in rats of all the model groups, but the control group was negative. Conclusions Rat model of Pseudomonas aeruginosa infected pneu?monia can be successfully established by intranasal inoculation. This method can avoid the inflammatory interference from operation, and is simple and suitable for popularization.

[Analysis of hemoptysis treated by bronchial arterial embolization].

OBJECTIVE: To investigate the correlation of effect of bronchial arterial embolization (BAE) in the treatment of hemoptysis and relative factors. METHODS: From December 2007 to August 2011, 105 patients with hemoptysis were admitted. BAE was carried out after bronchial artery arteriography and ensured bronchial artery anomaly. Patients were followed up 3 to 24 months. RESULTS: All 105 cases were confirmed abnormal bronchial artery. And 101 cases (96.2%) were completed BAE, and among them, 91 cases (86.7%) were stop bleeding , and 7 cases (6.7%) were excellence. The total effective rate was 93.4%.In follow-up period, there were 69 cases (65.7%) without recurrence, and 8 cases (7.6%) were recent recurrence and 10 cases (9.5%) were long-term recurrence, respectively. All factors were no obvious correlation to effect of BAE. CONCLUSION: BAE is an effective treatment for hemoptysis.Effect of the BAE was irrespective to related factors.