RESUMO
Two new hydroquinones bearing a 1,3-enyne moiety, pestalotioquinols G and H, together with four known compounds, including pestalotioquinol A, phomonitroester, (R)-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one, and scylatone were isolated from the marine fungus Pestalotiopsis diploclisia (BCC 35283). The structures of these compounds were elucidated by analysis of 2D-NMR and HR-MS data. The known pestalotioquinol A displayed antimalarial activity against Plasmodium falciparum K1 with an IC50 value of 19.0 µM, while pestalotioquinol G displayed weak cytotoxic activity against Vero cell lines with an IC50 value of 47.9 µM.
Assuntos
Fungos , Hidroquinonas , Estrutura Molecular , Fungos/química , Pestalotiopsis , PlantasRESUMO
Four xanthones (1â4) and a known compound, mansonone D (5), were isolated from the lignicolous freshwater fungus BCC 28210 (family, Chaetosphaeriaceae). The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the isolated metabolites, compound 2 and the known mansonone D (5) displayed antimalarial activity against Plasmodium falciparum K1 with IC50 values of 7.75 and 0.55 µg/mL, respectively. Compound 4 displayed antibacterial activity against Bacillus cereus with an MIC value of 6.25 µg/mL.
Assuntos
Antibacterianos/isolamento & purificação , Antimaláricos/isolamento & purificação , Ascomicetos/química , Xantonas/isolamento & purificação , Antibacterianos/química , Antimaláricos/química , Ascomicetos/metabolismo , Bacillus cereus/efeitos dos fármacos , Água Doce/microbiologia , Concentração Inibidora 50 , Testes de Sensibilidade Microbiana , Estrutura Molecular , Naftoquinonas/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Plasmodium falciparum/efeitos dos fármacos , Xantonas/química , Xantonas/farmacologiaRESUMO
Stereumins Q-U, together with known stereumins A, B, K, L, and N, as well as ent-strobilols E and G were isolated from the culture of Stereum cf. sanguinolentum BCC 22926. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of stereumins A and Q, as well as ent-strobilol E were established by application of the modified Mosher's method. Stereumin T displayed antibacterial activity against Bacilluscereus with a MIC value of 3.97µM.
Assuntos
Antibacterianos/isolamento & purificação , Bacillus cereus/efeitos dos fármacos , Basidiomycota/química , Sesquiterpenos/isolamento & purificação , Antibacterianos/química , Antibacterianos/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Sesquiterpenos Policíclicos , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Sesterterpenos , TailândiaRESUMO
Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50=14 microM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 microM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 microM.
Assuntos
Antivirais/isolamento & purificação , Ascomicetos/química , Compostos Heterocíclicos com 3 Anéis/isolamento & purificação , Animais , Antivirais/química , Antivirais/farmacologia , Chlorocebus aethiops , Herpesvirus Humano 1/efeitos dos fármacos , Compostos Heterocíclicos com 3 Anéis/química , Compostos Heterocíclicos com 3 Anéis/farmacologia , Humanos , Concentração Inibidora 50 , Células KB , Estrutura Molecular , Musa/microbiologia , Estereoisomerismo , Tailândia , Células VeroRESUMO
New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.
Assuntos
Antimaláricos/isolamento & purificação , Antituberculosos/isolamento & purificação , Compostos Bicíclicos Heterocíclicos com Pontes/isolamento & purificação , Compostos de Epóxi/isolamento & purificação , Compostos Heterocíclicos de Anel em Ponte/isolamento & purificação , Hypocreales/química , Plasmodium falciparum/efeitos dos fármacos , Compostos de Espiro/isolamento & purificação , Animais , Antimaláricos/química , Antimaláricos/farmacologia , Antineoplásicos/química , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Antituberculosos/química , Antituberculosos/farmacologia , Compostos Bicíclicos Heterocíclicos com Pontes/química , Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia , Candida albicans/efeitos dos fármacos , Chlorocebus aethiops , Ensaios de Seleção de Medicamentos Antitumorais , Compostos de Epóxi/química , Compostos Heterocíclicos de Anel em Ponte/química , Humanos , Concentração Inibidora 50 , Estrutura Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Testes de Sensibilidade Parasitária , Compostos de Espiro/química , Compostos de Espiro/farmacologia , Tailândia , Células VeroRESUMO
New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080. Structures of these compounds were elucidated by extensive MS and NMR spectroscopic analyses. Compound 1 displayed anti-HSV-1 activity with an IC(50) value of 7.2 microM. Compound 3 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 9.9 microM.
Assuntos
Acremonium/química , Antivirais/isolamento & purificação , Antivirais/farmacologia , Glicosídeos/isolamento & purificação , Glicosídeos/farmacologia , Herpesvirus Humano 1/efeitos dos fármacos , Fenóis/isolamento & purificação , Fenóis/farmacologia , Plasmodium falciparum/efeitos dos fármacos , Animais , Antivirais/química , Chlorocebus aethiops , Ensaios de Seleção de Medicamentos Antitumorais , Glicosídeos/química , Humanos , Hidroxibenzoatos/química , Hidroxibenzoatos/isolamento & purificação , Hidroxibenzoatos/farmacologia , Concentração Inibidora 50 , Estrutura Molecular , Fenóis/químicaRESUMO
Two novel diphenyl ether glycosides and a new diphenyl ether, cordyol A-C (1-3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 microg/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 microg/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 microg/ml.
