RESUMO
Objective: To study the spectrum-effect relationship and material basis of pharmacodynamic effect of Wuji Pills in the treatment of gastric ulcer in rat model. Methods: The analysis method for the fingerprint of 11 batches of Wuji Pills from different sources was built, and the rat model of gastric ulcer was used to investigate the pharmacodynamics of 11 batches of Wuji Pills. By system clustering method and gray relational analysis, efficacy data and relative peak areas of fingerprint common peaks of 11 batches of Wuji Pills were associated, and the related spectral efficiency relationship model was established. Results: The spectrum-effect relationship showed that the therapeutic effect of Wuji Pills on rat gastric ulcer was a result of a variety of ingredients, the effect of berberine hydrochloride in Coptis Rhizoma, Evodia rutaecarpa alkali in Euodiae Fructus, paeoniflorin in Paeoniae Alba Radix, etc could significantly reduce the content of pepsin in stomach tissue (PEP), which were the main effective components in Wuji Pills. Conclusion: The efficacy of active substances are obtained through the study on the relationship between spectrum and efficiency, establish the relationship between spectrum and efficiency evaluation of Wuji Pills, and the method provides important reference for the research of traditional Chinese medicine preparation.
