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s:Objective To explore the anatomical distribution characteristics of pelvic endometriosis lesion, size of the cyst, tissue ad-hesion degree and the correlation with the pain symptoms in patients with ovarian endometriosis cyst. Methods 342 cases of patients with o-varian endometriosis cyst who has underwent gynecologic laparoscopic surgical treatment in our hospital were selected as the research objects. According to the pain symptoms, they were divided into the pain group (195 cases) and the painless group (147 cases). The influence of cyst growth area and size on the pain symptoms were compared, and whether there were cyst adhesion and the relationship between adhesion area and pain were analyzed. Results The operation time of pain group was longer. The average operation time was 81. 2 min in pain group while it was 62. 1 min in painless group. The bleeding volum was 74. 3 mL in pain group which was higher than 56. 2 mL in the painless group. The average diameter of cyst was 11. 26 cm in the Pain group, and it was 6. 10 cm painless group. Rate of adhesions in patients of pain group was significantly higher than that of the painless group. Adhesion occured most frequently in ovary, followed by the fallopian tubes. Conclusion Pain symptoms have a close relation with cyst diameter and degree of surrounding tissue adhesion. As the cyst diameter get larger and the surrounding tissue adhesions grow broader, the pain symptoms would be more significant in patients .
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PURPOSE: This paper is to study the pharmacokinetic features of baicalin in lens through observing baicalin's concentration changes in lens of rabbits following intragastric administration. METHODS: Forty-four rabbits were randomly divided into 11 groups. The lens were collected at the beginning without any intragastric administration, and then collected after 15 minutes following intragastric administration of 80 mg/kg baicalin, and continually collected individually after 0.5,0.75,1,1.5,2,3,5,8,12 hours: the concentration of baicalin was measured by reversed-phase high-performance liquid chromatography (RP-HPLC). RESULTS: There were two obvious peaks in the drug concentration-time diagram, appearing respectively at half an hour and 2 hours after the intragastric administration. The highest level of baicalin's concentration in lens (C( max ), = 4.997 microg/ml) was obtained 0.9 hour (T( max ) = 0.906 h) after application of baicalin. Area under the concentration time curve (AUC), half-life of the drug elimination (T( 1/2 )) and clearance ratio were 3.542 microg/ml*h., 1.576 h and 8.114 l/h respectively. CONCLUSIONS: Baicalin can penetrate blood-eye barriers and enter the lens following intragastric administration.
