RESUMO
Amide is a fundamental group that is present in molecular structures of all domains of organic chemistry and the construction of this motif with high atom economy is the focus of the current research. Specifically, N-methyl amides are valuable building blocks in natural products and pharmaceutical science. Due to the volatile nature of methyl amine, the generation of N-methyl amides using simple acids with high atom economy is rare. Herein, we disclose an atom economic protocol to prepare this valuable motif under DABCO/Fe3O4 cooperative catalysis. This protocol is operationally simple and compatible with a range of aliphatic and (hetero)aromatic acids with very good yields (60-99%). Moreover, the Fe3O4 can be easily recovered and high efficiency is maintained for up to ten cycles.
RESUMO
Objective:To observe the clinical effects and adverse reactions of meropenem in the treatment of severe lung infection. Methods:Totally 62 severe bacterial lung infection patients were randomly divided into two groups randomly. The patients in the con-trol group (31 cases ) were treated with cefoperazone / sulbactam 2-8 g in 100 ml 0. 9% sodium chloride injections,ivd,q12h, and the treatment group (31 cases ) was treated with meropenem 1 g in 100 ml 0. 9% sodium chloride injections,ivd,q8h. The treatment course was 14 days. The bacterial clearance rate, dual infection rate, clinical efficacy and adverse drug reactions of the two groups were observed and compared. Results:The bacterial clearance rate in the control group was 85. 2% and that in the treatment group was 92. 85% (P>0. 05). The incidence rate of dual infection in the treatment group (3. 6%) was significant lower than that in the control group (P0. 05). Conclusion:Meropenem is ef-fective in the treatment of severe bacterial lung infection. It can clear bacteria and reduce dual infection effectively, which shows better efficacy than cefoperazone / sulbactam.
