RESUMO
Intramolecular redox reaction: heating N-alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions results in the formation of NH-S-alkyl sulfoximines. The intramolecular redox reaction involves a hydride transfer that occurs by a 6-endo-trig process. The intermediates in the reaction can also give access to four- and six-membered heterocyclic rings and a new class of chiral dienes.
RESUMO
The first total synthesis of buddledone A was accomplished in seven steps from methyl ethyl ketone (MEK). The key step in the sequence featured an 11-membered ring formation by ring-closing metathesis.
Assuntos
Butanonas/química , Sesquiterpenos/síntese química , Buddleja/química , Catálise , Ciclização , Estrutura Molecular , Sesquiterpenos/químicaRESUMO
Fluorescent 7-amino-2,1-benzothiazines were prepared in high yields using the palladium-catalyzed reaction of 4-amino-2-chlorobenzaldehydes with a sulfoximine or the reaction of 7-fluoro-2,1-benzothiazines with amines.
Assuntos
Corantes Fluorescentes/síntese química , Tiazinas/síntese química , Catálise , Estrutura Molecular , Paládio/químicaRESUMO
The efficient N-arylation of a sulfoximine with aryl chlorides was developed by using Pd(2)(dba)(3) as a catalyst and various ligands. The reactions using RuPhos as a ligand afforded the coupled products in fair to excellent yields.