1.
J Nanosci Nanotechnol
; 10(5): 3294-8, 2010 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20358942
RESUMO
Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.