RESUMO
A 55-year-old woman visited our hospital for an investigation of central bronchiectasis, mucoid impaction and infiltrative shadows on chest CT. She had a 10-year history of bronchial asthma; however, her adherence to treatment was poor. Based on the presence of peripheral blood eosinophilia and immediate cutaneous reactivity to Aspergillus fumigatus, the patient was clinically diagnosed with allergic bronchopulmonary aspergillosis. Her condition and CT findings improved with systemic corticosteroid therapy. It was found that the patient had not been sensitized to Aspergillus 10 years earlier, indicating that single testing is inadequate for the early diagnosis of this disease.
Assuntos
Aspergilose Broncopulmonar Alérgica/etiologia , Bronquiectasia/etiologia , Corticosteroides/uso terapêutico , Alérgenos/imunologia , Anticorpos Antifúngicos/sangue , Antígenos de Fungos/imunologia , Aspergilose Broncopulmonar Alérgica/diagnóstico , Aspergilose Broncopulmonar Alérgica/imunologia , Aspergillus fumigatus/imunologia , Asma/complicações , Asma/imunologia , Bronquiectasia/imunologia , Feminino , Humanos , Hipersensibilidade Imediata , Imunoglobulina E/sangue , Pessoa de Meia-Idade , Testes Cutâneos , Fatores de Tempo , Tomografia Computadorizada por Raios XRESUMO
It has been postulated that interferon induces depression via a nitric oxide-related system. The purpose of this study was to test whether there was a difference in the effects of interferon-alpha (IFN-alpha) on nitric oxide production between patients with and without interferon-induced depression. The subjects had chronic hepatitis C and were being treated with IFN-alpha. We measured plasma nitrate, a marker of nitric oxide production in vivo, before, during, and after interferon therapy. Of 146 patients, 9 developed depression within the first 4 wk of interferon therapy, and 8 developed depression later. In the former group, a significant plasma nitrate increase was observed during therapy, followed by a decrease to baseline after discontinuation. This, however, was not the case with the latter group or those who had no psychiatric symptoms. These results suggest nitric oxide involvement in at least some forms of IFN-alpha-induced depression.
Assuntos
Transtorno Depressivo/induzido quimicamente , Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/efeitos adversos , Óxido Nítrico/sangue , Adolescente , Adulto , Amitriptilina/uso terapêutico , Antidepressivos Tricíclicos/uso terapêutico , Clomipramina/uso terapêutico , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/tratamento farmacológico , Transtorno Depressivo/fisiopatologia , Feminino , Humanos , Imipramina/uso terapêutico , Interferon-alfa/uso terapêutico , Masculino , Nitratos/sangue , Nitritos/sangue , Valores de ReferênciaAssuntos
Antagonistas Colinérgicos/efeitos adversos , Discinesia Induzida por Medicamentos/etiologia , Risperidona/efeitos adversos , Esquizofrenia/tratamento farmacológico , Adulto , Biperideno/efeitos adversos , Biperideno/uso terapêutico , Antagonistas Colinérgicos/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Exame Neurológico/efeitos dos fármacos , Risperidona/uso terapêutico , Triexifenidil/efeitos adversos , Triexifenidil/uso terapêuticoRESUMO
Apresenta a estratégia de reorganizaçäo de enfrentamento às doenças infecciosas no Estado do Paraná. Aliando-se a várias entidades ligadas a saúde constituiu-se uma organizaçäo em forma de rede, para o controle das doenças infecciosas, buscando maior eficácia de intervençäo com resolubilidade dessas doenças (MMSC)
