1.
Intern Med
; 42(3): 268-72, 2003 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12705793
RESUMO
A young man with repetitive deep venous thrombosis of the legs and the inferior vena cava, and his family were eventually diagnosed by means of molecular genetic analysis as having both hereditary protein C and protein S deficiency. There have been a few reports of families with combined protein C and protein S deficiency and only one report of such a family characterized at the DNA level. This was the first reported family in Japan with combined deficiency of protein C and protein S accompanied by segregation of gene lesions.