A set of web-based public decision support tools for integrated planning and management in aquaculture.

We developed a set of web-based tools to meet the demand for spatial planning and help to determine the available space suitable for marine aquaculture activity. These tools were derived from AkvaVis concept, which was initially designed for the management of Norwegian aquaculture. The AkvaVis concept was adapted to different national aquaculture contexts and two other tools were developed in France and China. Besides using GIS maps and thematic layers, interactive functions were added to enable the user to select spatial parameters, build indicators for aquaculture siting and instantly display the requested information. For each tool, we describe the main technical features, input data, data geoprocessing, output products, tool strengths and limits, and applicability to other case studies. The three tools we present share common concepts and features:•use of standardized protocols for data (Web Feature Services, Web Map Services)•reusability of the modules developed for applications to other case studies•web-based interface for spatial data viewing and processingThey also show some differences, e.g., the Chinese tool exists as a desktop or a web-based support system. Differences and demonstrations for different aquaculture contexts in Europe and China offer some flexibility in future applications.

Attention driven foveated video quality assessment.

Contrast sensitivity of the human visual system to visual stimuli can be significantly affected by several mechanisms, e.g., vision foveation and attention. Existing studies on foveation based video quality assessment only take into account static foveation mechanism. This paper first proposes an advanced foveal imaging model to generate the perceived representation of video by integrating visual attention into the foveation mechanism. For accurately simulating the dynamic foveation mechanism, a novel approach to predict video fixations is proposed by mimicking the essential functionality of eye movement. Consequently, an advanced contrast sensitivity function, derived from the attention driven foveation mechanism, is modeled and then integrated into a wavelet-based distortion visibility measure to build a full reference attention driven foveated video quality (AFViQ) metric. AFViQ exploits adequately perceptual visual mechanisms in video quality assessment. Extensive evaluation results with respect to several publicly available eye-tracking and video quality databases demonstrate promising performance of the proposed video attention model, fixation prediction approach, and quality metric.

Bear bile inhibits the immunosuppression activity of hepatic stellate cells in vivo.

BACKGROUND/AIMS: In the injured liver, hepatic stellate cells (HSCs) induce immunosuppression activity and thus participate in the pathogenesis of liver disease, including HCC. Therefore, finding new drugs to inhibit their immunosuppression activity is necessary. This study tests whether bear bile can affect the immunosuppression activities of HSCs. METHODOLOGY: The mice were gavaged with bear bile for 4 weeks. The expression of HSCs was detected through desmin and ±-smooth muscle antibody immunohistochemistry. HSCs were isolated from these mice liver and then cultured with T cells in a mixed leukocyte reaction for 3 days. Stellate cell surface makers, T-cell apoptosis, regulatory T cells and the ability of T cells to kill hepatocellular carcinoma were determined via flow cytometry. Cytokines were determined by a mouse cytokine array panel and T-cell proliferation was determined through a BrdU kit. RESULTS: Bear bile decreased HSCs and their surface molecules, and affected cytokine secretion. Interestingly, HSCs from the mice gavaged with bear bile promoted T-cell proliferation, inhibited T-cell apoptosis, decreased CD4+CD25+Foxp3+ regulatory T cells and enhanced the activation of T cells killing hepatocellular carcinoma. CONCLUSIONS: Bear bile can inhibit the immunosuppression activity of HSCs and enhance immune response especial anti-tumor immune response.

Scale- and rotation-invariant local binary pattern using scale-adaptive texton and subuniform-based circular shift.

This paper proposes an effective scale- and rotation-invariant local binary pattern (LBP) feature for texture classification. A circular neighboring set of an image pixel is defined as a scale-adaptive texton by taking into account the fundamental local structure property of the pixel. The scale space of a texture image is derived by the Laplacian of the Gaussian and then employed to determine the optimal scale of each pixel reflecting the characteristic length of the corresponding structure and determining the radius of the scale-adaptive texton. Different pixels have different optimal scales, resulting in the scale invariance. Contrary to the traditional LBP features that usually ignore global spatial information, the proposed method also defines subuniform patterns of each uniform pattern to improve the discrimination. For each uniform pattern, the subuniform pattern with the maximum statistical value is defined as the dominant orientation subuniform pattern. It is moved to the first column, and the others are circularly shifted. Experimental results demonstrate a good discrimination capability of the proposed scale- and rotation-invariant LBP in texture classification. Particularly, the LBP based on the scale-adaptive texton is promising to be powerful for texture description and scale-invariant texture classification, and the circular shift subuniform LBP can further improve the performance in the rotation-invariant texture classification.

Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice.

Activated hepatic stellate cells (HSCs) play a central role in the hepatic fibrosis and cirrhosis. Recently, HSCs were reported to have strong immune modulatory activities. However, the role of HSCs in hepatocellular carcinoma (HCC) remains unclear. In this study, we showed that HSCs could promote HCC growth both in vitro and in vivo. We examined the HSC-mediated inhibition of T-cell proliferation and the ability of conditioned medium from activated HSCs to promote the growth of murine HCC cell lines in vitro. We also assessed the immune suppression by HSCs during the development of HCC in immunocompetent mice. Cotransplantation of HSCs promoted HCC growth and progression by enhancing tumor angiogenesis and tumor cell proliferation and by creating an immunosuppressed microenvironment. Cotransplanted HSCs inhibited the lymphocyte infiltration in tumors and the spleens of mice bearing tumors, induced apoptosis of infiltrating mononuclear cells, and enhanced the expression of B7H1 and CD4(+) CD25(+) Treg cells. The immune modulation by HSCs seemed to be systemic. In conclusion, our data provide new information to support an integral role for HSCs in promoting HCC progression in part via their immune regulatory activities, and suggest that HSCs may serve as a therapeutic target in HCC.