Minocycline/Amoxicillin-Based Bismuth Quadruple Therapy for Helicobacter pylori Eradication: A Pilot Study.

The common adverse effects and the complicated administration of tetracycline and metronidazole greatly affect the clinical application of the classical bismuth quadruple therapy (BQT) for Helicobacter pylori eradication. This pilot study aimed to evaluate the efficacy and safety of minocycline/amoxicillin-based BQT for H. pylori eradication. Firstly, consecutive H. pylori isolates collected at West China Hospital of Sichuan University between 2018 and 2021 were included for susceptibility testing of tetracycline and minocycline using E-test strips. Secondly, both treatment-naïve and experienced patients were included to receive a 14-day minocycline/amoxicillin-based BQT: esomeprazole 40 mg or vonoprazan 20 mg, bismuth colloidal pectin 300 mg, amoxicillin 1000 mg, and minocycline 100 mg, all given twice daily. Among a total of 101 H. pylori isolates, tetracycline resistance was 3.0%, whereas minocycline resistance was nil. A total of 114 patients (treatment-naïve/experienced, 72/42) received the minocycline/amoxicillin-based BQT. The overall intention-to-treat (ITT) and per protocol (PP) eradication rates were 94.7% (108/114) and 97.3% (108/111), respectively. The ITT and PP eradication rates were 91.7% (66/72) and 95.7% (66/69) among the treatment-naïve patients, and both were 100.0% among the treatment-experienced patients. No serious adverse event was recorded. This pilot study suggests that minocycline/amoxicillin-based BQT is an excellent therapy for H. pylori eradication.

Fast and Accurate Light Field View Synthesis by Optimizing Input View Selection.

There is a trade-off between spatial resolution and angular resolution limits in light field applications; various targeted algorithms have been proposed to enhance angular resolution while ensuring high spatial resolution simultaneously, which is also called view synthesis. Among them, depth estimation-based methods can use only four corner views to reconstruct a novel view at an arbitrary location. However, depth estimation is a time-consuming process, and the quality of the reconstructed novel view is not only related to the number of the input views, but also the location of the input views. In this paper, we explore the relationship between different input view selections with the angular super-resolution reconstruction results. Different numbers and positions of input views are selected to compare the speed of super-resolution reconstruction and the quality of novel views. Experimental results show that the speed of the algorithm decreases with the increase of the input views for each novel view, and the quality of the novel view decreases with the increase of the distance from the input views. After comparison using two input views in the same line to reconstruct the novel views between them, fast and accurate light field view synthesis is achieved.