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IET Syst Biol ; 5(5): 317-23, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22010758

RESUMO

Based on the similarity between a reentrant wave in cardiac tissue and a vortex in fluid dynamics, the authors hypothesised that a new non-dimensional index, like the Reynolds number in fluid dynamics, may play a critical role in categorising reentrant wave dynamics. Therefore the goal of the present study is to devise a new index to characterise electric wave conduction in cardiac tissue and examined whether this index can be used as a biomarker for categorising the reentrant wave pattern in cardiac tissue. Similar to the procedure used to derive the Reynolds number in fluid dynamics, the authors used a non-dimensionalisation technique to obtain the new index. Its usefulness was verified using a two-dimensional simulation model of electrical wave propagation in cardiac tissue. The simulation results showed that electrical waves in cardiac tissue move into an unstable region when the index exceeds a threshold value.


Assuntos
Sistema de Condução Cardíaco/fisiologia , Coração/fisiologia , Modelos Cardiovasculares , Potenciais de Ação , Arritmias Cardíacas/fisiopatologia , Biomarcadores/metabolismo , Cardiologia/métodos , Biologia Computacional , Simulação por Computador , Eletrofisiologia/métodos , Humanos , Modelos Teóricos , Padrões de Referência , Reologia/métodos , Biologia de Sistemas/métodos
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