RESUMO
A common celiomesenteric trunk (CMT) is one of the several anatomic variations in the mesenteric circulation and occurs when the celiac and superior mesenteric arteries originate from a single common trunk. Because of its rarity, few lesions of the CMT have been reported. We herein present a case of atherosclerotic stenosis of the CMT of an 81-year-old female who presented with symptoms of mesenteric angina. To our knowledge, this represents the first reported case of endovascular treatment of CMT stenosis.
Assuntos
Angioplastia com Balão , Artéria Celíaca , Procedimentos Endovasculares , Isquemia/terapia , Artéria Mesentérica Superior , Oclusão Vascular Mesentérica/terapia , Idoso de 80 Anos ou mais , Angioplastia com Balão/instrumentação , Artéria Celíaca/anormalidades , Artéria Celíaca/diagnóstico por imagem , Constrição Patológica , Procedimentos Endovasculares/instrumentação , Feminino , Humanos , Isquemia/diagnóstico por imagem , Isquemia/etiologia , Artéria Mesentérica Superior/anormalidades , Artéria Mesentérica Superior/diagnóstico por imagem , Oclusão Vascular Mesentérica/complicações , Oclusão Vascular Mesentérica/diagnóstico por imagem , Radiografia , Resultado do TratamentoRESUMO
The effects of graduated compression stockings (GCS) on venous blood velocity have not been established. In healthy subjects, most investigations showed no effect on blood velocity, but mixed results have been reported. In this investigation we to test the hypothesis that popliteal blood velocity is increased by properly fitted GCS. Time average peak velocity in the popliteal vein, as well as time average mean velocity, vein diameter and mean volumetric flow were measured by pulsed wave Doppler ultrasound in 25 healthy male volunteers without compression stockings and repeated with fitted thigh-length compression stockings. Measurements were obtained while supine and while sitting at rest and during ankle exercise. Thigh-length GCS did not increase popliteal vein blood velocity, diameter, or volumetric blood flow while supine or sitting, with or without ankle exercise.
Assuntos
Velocidade do Fluxo Sanguíneo , Veia Poplítea/fisiologia , Fluxo Sanguíneo Regional , Meias de Compressão , Adulto , Exercício Físico , Humanos , Masculino , Veia Poplítea/diagnóstico por imagem , Valores de Referência , Decúbito Dorsal , Fatores de Tempo , Ultrassonografia Doppler de Pulso , Adulto JovemRESUMO
The electrostatic properties of seven alpha/beta-barrel enzymes selected from different evolutionary families were studied: triose phosphate isomerase, fructose-1,6-bisphosphate aldolase, pyruvate kinase, mandelate racemase, trimethylamine dehydrogenase, glycolate oxidase, and narbonin, a protein without any known enzymatic activity. The backbone of the alpha/beta-barrel has a distinct electrostatic field pattern, which is dipolar along the barrel axis. When the side chains are included in the calculations the general effect is to modulate the electrostatic pattern so that the electrostatic field is generally enhanced and is focused into a specific area near the active site. We use the electrostatic flux through a square surface near the active site to gauge the functionally relevant magnitude of the electrostatic field. The calculations reveal that in six out of the seven cases the backbone itself contributes greater than 45% of the total flux. The substantial electrostatic contribution of the backbone correlates with the known preference of alpha/beta-barrel enzymes for negatively charged substrates.
