Global tropical cyclone extreme wave height climatology.

A global study of extreme value (1 in 100-year return period) tropical cyclone generated waves is conducted across all tropical cyclone basins. The study uses a 1000 year tropical cyclone synthetic track database to force a validated parametric wave model. The resulting distributions of extreme significant wave height show that values in the North Atlantic and Western Pacific basins are the largest globally. This is partly due to the relative intensities and frequencies of occurrence of storms in these basins but also because the typical velocities of forward movement of storms are larger and hence can sustain the generation of larger waves. These larger values of velocity of forward movement tend to occur at higher latitudes. As a result, in both of these basins the largest extreme waves occur at higher latitudes than the maximum tropical cyclone winds. In all other tropical cyclone basins, storms tend to propagate more east-west and hence the maximum values of extreme significant wave height and wind speed occur at comparable latitudes.

A dataset of global tropical cyclone wind and surface wave measurements from buoy and satellite platforms.

There are now a range of potential data sources for wind and surface wave conditions within tropical cyclones. These sources include: in situ buoy data and remote sensing data from satellite altimeters, scatterometers, and radiometers. In addition, data providing estimates of tropical cyclone tracks and wind field parameters are available from best track archives. The present dataset brings together this information in a single archive, providing the available data for each tropical cyclone from each of the data sources in a single file. The data consists of observations in a total of 2927 global tropical cyclones over the period from 1985 to 2017. Global statistics of the observations are provided, along with data on the geographic distribution of tropical cyclones within the database.

An 8-model ensemble of CMIP6-derived ocean surface wave climate.

We present a global wind wave climate model ensemble composed of eight spectral wave model simulations forced by 3-hourly surface wind speed and daily sea ice concentration from eight different CMIP6 GCMs. The spectral wave model uses ST6 physics parametrizations and a global three-grid structure for efficient Arctic and Antarctic wave modeling. The ensemble performance is evaluated against a reference global multi-mission satellite altimeter database and the recent ECMWF IFS Cy46r1 ERA5 wave hindcast, ERA5H. For each ensemble member three 30-year slices, one historical, and two future emission scenarios (SSP1-2.6 and SSP5-8.5) are available, and cover two distinct periods: 1985-2014 and 2071-2100. Two models extend to 140 years (1961-2100) of continuous wind wave climate simulations. The present ensemble outperforms a previous CMIP5-forced wind wave climate ensemble, showing improved performance across all ocean regions. This dataset is a valuable resource for future wind wave climate research and can find practical applications in offshore and coastal engineering projects, providing crucial insights into the uncertainties connected to wind wave climate future projections.

Positive relationship between seasonal Indo-Pacific Ocean wave power and SST.

The influence of increasing sea surface temperatures (SSTs), in response to greenhouse warming, on wave power (WP) remains uncertain. Here, seasonal relationships between SST anomalies and mean and extreme WP over the Indo-Pacific Ocean are examined. Overall, seasonal WP has significantly increased over much of the Pacific, Indian, and Southern Ocean by 1.21-3.10 kW/m dec-1 over 1979-2019. Contributions from wave characteristics, namely significant wave height (SWH) and peak wave period (PWP), to changes in WP show that SWH contributes most in extra-tropical regions, and PWP most in tropical regions. Further, seasonal relationships between SST anomalies and WP indicate that increases in WP are also seen during strong El Niño years in December-February, and in-phase combinations of El Niño and positive Indian Ocean Dipole (IOD) events during June-August and September-November. Results highlight both long-term increasing SSTs and climate variability roles for inducing large-scale seasonal WP changes throughout the Indo-Pacific.

New options for increasing the sensitivity, specificity and scope of synergistic contrast magnetic resonance imaging (scMRI) using Multiplied, Added, Subtracted and/or FiTted (MASTIR) pulse sequences.

This paper reviews magnetic resonance (MR) pulse sequences in which the same or different tissue properties (TPs) such as T1 and T2 are used to contribute synergistically to lesion contrast. It also shows how synergistic contrast can be created with Multiplied, Added, Subtracted and/or fiTted Inversion Recovery (MASTIR) sequences, and be used to improve the sensitivity, specificity and scope of clinical magnetic resonance imaging (MRI) protocols. Synergistic contrast can be created from: (i) the same TP, e.g., T1 used twice or more in a pulse sequence; (ii) different TPs such as ρm, T1, T2, and D* used once or more within a sequence, and (iii) additional suppression or reduction of signals from tissues and/or fluids such as fat, long T2 tissues and cerebrospinal fluid (CSF). The short inversion time (TI) inversion recovery (IR) (STIR) and double IR (DIR) sequences usually show synergistic positive contrast for lesions which have increases in both T1 and T2. The diffusion weighted pulsed gradient spin echo (PGSE) sequence shows synergistic contrast for lesions which have an increase in T2 and a decrease in D*; the sequence is both positively weighted for T2 and negatively weighted for D*. In the brain, when an IR sequence nulling white matter has subtracted from it an IR sequence nulling gray matter to form the subtracted IR (SIR) sequence, increases in the single TP T1 between the two nulling points of the original two sequences generate high synergistic positive contrast. In addition, the subtraction to produce the SIR sequence reduces fat and CSF signals. To provide high sensitivity to changes in TPs in disease the SIR sequence can be used (i) alone to provide synergistic T1 contrast as above; (ii) with T2-weighting to provide synergistic T1 and T2 contrast, and (iii) with T2- and D*-weighting to provide synergistic T1, T2, and D* contrast. The SIR sequence can also be used in reversed form (longer TI form minus shorter TI form) to produce very high positive synergistic T1 contrast for reductions in T1, and so increase the positive contrast enhancement produced by clinical gadolinium-based contrast agents (GBCAs) when they reduce T1. The specificity of MRI examinations can be improved by using the reversed SIR sequence with a long echo time (TE) gradient echo as well as echo subtraction to show synergistic high contrast from T1 and T2* shortening produced by organic iron. Other added and subtracted forms of the MASTIR sequence can be used synergistically to selectively show myelin, myelin water and fluids including blood and CSF. Protocols using MASTIR sequences to provide synergistic contrast in MRI of the brain, prostate and articular cartilage are included as illustrative examples, and the features of synergistic contrast MRI (scMRI) are compared to those of multiparametric MRI (mpMRI) and functional MRI (fMRI).

Projections of global-scale extreme sea levels and resulting episodic coastal flooding over the 21st Century.

Global models of tide, storm surge, and wave setup are used to obtain projections of episodic coastal flooding over the coming century. The models are extensively validated against tide gauge data and the impact of uncertainties and assumptions on projections estimated in detail. Global "hotspots" where there is projected to be a significant change in episodic flooding by the end of the century are identified and found to be mostly concentrated in north western Europe and Asia. Results show that for the case of, no coastal protection or adaptation, and a mean RCP8.5 scenario, there will be an increase of 48% of the world's land area, 52% of the global population and 46% of global assets at risk of flooding by 2100. A total of 68% of the global coastal area flooded will be caused by tide and storm events with 32% due to projected regional sea level rise.

Use of Multiplied, Added, Subtracted and/or FiTted Inversion Recovery (MASTIR) pulse sequences.

The group of Multiplied, Added, Subtracted and/or fiTted Inversion Recovery (MASTIR) pulse sequences in which usually two or more inversion recovery (IR) images of different types are combined is described, and uses for this type of sequence are outlined. IR sequences of different types can be multiplied, added, subtracted, and/or fitted together to produce variants of the MASTIR sequence. The sequences provide a range of options for increasing image contrast, demonstrating specific tissues and fluids of interest, and suppressing unwanted signals. A formalism using the concept of pulse sequences as tissue property filters is used to explain the signal, contrast and weighting of the pulse sequences with both univariate and multivariate filter models. Subtraction of one magnitude reconstructed IR image from another with a shorter TI can produce very high T1 dependent positive contrast from small increases in T1. The reverse subtracted IR sequence can provide high positive contrast enhancement with gadolinium chelates and iron deposition which decrease T1. Additional contrast to that arising from increases in T1 can be produced by supplementing this with contrast arising from concurrent increases in ρm and T2, as well as increases or decreases in diffusion using subtraction IR with echo subtraction and/or diffusion subtraction. Phase images may show 180º differences as a result of rotating into the transverse plane both positive and negative longitudinal magnetization. Phase images with contrast arising in this way, or other ways, can be multiplied by magnitude IR images to increase the contrast of the latter. Magnetization Transfer (MT) and susceptibility can be used with IR sequences to improve contrast. Selective images of white and brown adipose tissue lipid and water components can be produced using different TIs and in and out-of-phase TEs. Selective images of ultrashort and short T2 tissue components can be produced by nulling long T2 tissue components with an inversion pulse and subtraction of images with longer TEs from images with ultrashort TEs. The Double Echo Sliding IR (DESIRE) sequence provides images with a wide range of TIs from which it is possible to choose values of TI to achieve particular types of tissue and/or fluid contrast (e.g., for subtraction with different TIs, as described above, and for long T2 tissue signal nulling with UTE sequences). Unwanted tissue and fluid signals can be suppressed by addition and subtraction of phase-sensitive (ps) and magnitude reconstructed images. The sequence also offers options for synergistic use of the changes in blood and tissue ρm, T1, T2/T2*, D* and perfusion that can be seen with fMRI of the brain. In-vivo and ex-vivo illustrative examples of normal brain, cartilage, multiple sclerosis, Alzheimer's disease, and peripheral nerve imaged with different forms of the MASTIR sequence are included.

Projected 21st century changes in extreme wind-wave events.

We describe an innovative approach to estimate global changes in extreme wave conditions by 2100, as a result of projected climate change. We generate a synthetic dataset from an ensemble of wave models forced by independent climate simulation winds, enhancing statistical confidence associated with projected changes in extreme wave conditions. Under two IPCC representative greenhouse gas emission scenarios (RCP4.5 and RCP8.5), we find that the magnitude of a 1 in 100-year significant wave height (H s ) event increases by 5 to 15% over the Southern Ocean by the end of the 21st century, compared to the 1979-2005 period. The North Atlantic shows a decrease at low to mid latitudes (≈5 to 15%) and an increase at high latitudes (≈10%). The extreme significant wave height in the North Pacific increases at high latitudes by 5 to 10%. The ensemble approach used here allows statistical confidence in projected changes of extremes.

Pulse sequences as tissue property filters (TP-filters): a way of understanding the signal, contrast and weighting of magnetic resonance images.

This paper describes a quantitative approach to understanding the signal, contrast and weighting of magnetic resonance (MR) images. It uses the concept of pulse sequences as tissue property (TP) filters and models the signal, contrast and weighting of sequences using either a single TP-filter (univariate model) or several TP-filters (the multivariate model). For the spin echo (SE) sequence using the Bloch equations, voxel signal intensity is plotted against the logarithm of the value of the TPs contributing to the sequence signal to produce three TP-filters, an exponential ρm-filter, a low pass T1-filter and a high pass T2-filter. Using the univariate model which considers signal changes in only one of ρm, T1, or T2 at a time, the first partial derivative of signal with respect to the natural logarithm of ρm, T1 or T2 is the sequence weighting for each filter (for small changes in each TP). Absolute contrast is then the sequence weighting multiplied by the fractional change in TP for each filter. For large changes in TPs, the same approach is followed, but using the mean slope of the filter as the sequence weighting. These approaches can also be used for fractional contrast. The univariate TP-filter model provides a mathematical framework for converting conventional qualitative univariate weighting as used in everyday clinical practice into quantitative univariate weighting. Using the multivariate model which considers several TP-filters together, the relative contributions of each TP to overall sequence and image weighting are expressed as sequence and imaging weighting ratios respectively. This is not possible with conventional qualitative weighting which is univariate. The same approaches are used for inversion recovery (IR), pulsed gradient SE, spoiled gradient echo (SGE), balanced steady state free precession, ultrashort echo time and other pulse sequences. Other TPs such as susceptibility, chemical shift and flow can be included with phase along the Y axis of the TP-filter. Contrast agent effects are also included. In the text TP-filters are distinguished from k-space filters, signal filters (S-filters) which are used in imaging processing as well as to describe windowing the signal width and level of images, and spatial filters. The TP-filters approach resolves many of the ambiguities and inconsistencies associated with conventional qualitative weighting and provides a variety of new insights into the signal, contrast and weighting of MR images which are not apparent using qualitative weighting. The TP-filter approach relates the preparation component of pulse sequences to voxel signal, and contrast between two voxels. This is complementary to k-space which relates the acquisition component of pulse sequences to the spatial properties of MR images and their global contrast.

Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping.

AIM: Cholangiocarcinoma is endemic in southeast Asia, generally developing from liver fluke infestation. However, diagnostic imaging of early-stage disease is challenging. The aim of this work is to investigate relaxometry (specifically, T2 mapping) as a method of exploiting the higher signal-to-noise ratio (SNR) of internal coils for improved reception of magnetic resonance signals, despite their non-uniform sensitivity. METHODS: Ex vivo T2 mapping was carried out at 3T on fixed resection specimens from Thai cholangiocarcinoma patients using an mGRASE sequence and an endoscope coil based on a thin-film magneto-inductive waveguide and designed ultimately for internal use. RESULTS: Disease-induced changes including granulomatous inflammation, intraepithelial neoplasia and intraductal tumours were correlated with histopathology, and relaxation data were compared with mono- and bi-exponential models of T2 relaxation. An approximately 10-fold local advantage in SNR compared to a 16-element torso coil was demonstrated using the endoscope coil, and improved tissue differentiation was obtained without contrast agents. CONCLUSION: The performance advantage above follows directly from the inverse relation between the component of the standard deviation of T2 due to thermal noise and the SNR, and offers an effective method of exploiting the SNR advantage of internal coils. No correction is required, avoiding the need for tracking, relaxing constraints on coil and slice orientation and providing rapid visualization.

Publisher Correction: 33 years of globally calibrated wave height and wind speed data based on altimeter observations.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

33 years of globally calibrated wave height and wind speed data based on altimeter observations.

This dataset consists of 33 years (1985 to 2018), of global significant wave height and wind speed obtained from 13 altimeters, namely: GEOSAT, ERS-1, TOPEX, ERS-2, GFO, JASON-1, ENVISAT, JASON-2, CRYOSAT-2, HY-2A, SARAL, JASON-3 and SENTINEL-3A. The altimeter data have been calibrated and validated against National Oceanographic Data Center (NODC) buoy data. Differences between altimeter and buoy data as a function of time are investigated for long-term stability. A cross validation between altimeters is also carried out in order to check the stability and consistency of the calibrations developed. Quantile-quantile comparisons between altimeter and buoy data as well as between altimeters are undertaken to test consistency of probability distributions and extreme value performance. The data were binned into 1° by 1° bins globally, to provide convenient access for users to download only the regions of interest. All data are quality controlled. This globally calibrated and cross-validated dataset provides a single point of storage for all altimeter missions in a consistent format.

Multiplatform evaluation of global trends in wind speed and wave height.

In this study, global satellite data were analyzed to determine trends in oceanic wind speed and significant wave height over the 33-year period from 1985 to 2018. The analysis uses an extensive database obtained from 31 satellite missions comprising three types of instruments-altimeters, radiometers, and scatterometers. The analysis shows small increases in mean wind speed and significant wave height over this period, with larger increases in extreme conditions (90th percentiles). The largest increases occur in the Southern Ocean. Confidence in the results is strengthened because the wind speed trends are confirmed by all three satellite systems. An extensive set of sensitivity analyses confirms that both the mean and 90th percentile trends are robust, with only small impacts caused by satellite calibration and sampling patterns.

A permanent MRI magnet for magic angle imaging having its field parallel to the poles.

A novel design of open permanent magnet is presented, in which the magnetic field is oriented parallel to the planes of its poles. The paper describes the methods whereby such a magnet can be designed with a field homogeneity suitable for Magnetic Resonance Imaging (MRI). Its primary purpose is to take advantage of the Magic Angle effect in MRI of human extremities, particularly the knee joint, by being capable of rotating the direction of the main magnetic field B0 about two orthogonal axes around a stationary subject and achieve all possible angulations. The magnet comprises a parallel pair of identical profiled arrays of permanent magnets backed by a flat steel yoke such that access in lateral directions is practical. The paper describes the detailed optimization procedure from a target 150mm DSV to the achievement of a measured uniform field over a 130mm DSV. Actual performance data of the manufactured magnet, including shimming and a sample image, is presented. The overall magnet system mounting mechanism is presented, including two orthogonal axes of rotation of the magnet about its isocentre.

Optothermal profile of an ablation catheter with integrated microcoil for MR-thermometry during Nd:YAG laser interstitial thermal therapies of the liver­an in-vitro experimental and theoretical study.

PURPOSE: Flexible microcoils integrated with ablation catheters can improve the temperature accuracy during local MR-thermometry in Nd:YAG laser interstitial thermal therapies. Here, the authors are concerned with obtaining a preliminary confirmation of the clinical utility of the modified catheter. They investigate whether the thin-film substrate and copper tracks of the printed coil inductor affect the symmetry of the thermal profile, and hence of the lesion produced. METHODS: Transmission spectroscopy in the near infrared was performed to test for the attenuation at 1064 nm through the 25 µm thick Kapton substrate of the microcoil. The radial transmission profile of an infrared high-power, light emitting diode with >80% normalized power at 1064 nm was measured through a cross section of the modified applicator to assess the impact of the copper inductor on the optical profile. The measurements were performed in air, as well as with the applicator surrounded by two types of scattering media; crystals of NaCl and a layer of liver-mimicking gel phantom. A numerical model based on Huygens-Fresnel principle and finite element simulations, using a commercially available package (COMSOL Multiphysics), were employed to compare with the optical measurements. The impact of the modified optical profile on the thermal symmetry was assessed by examining the high resolution microcoil derived thermal maps from a Nd:YAG laser ablation performed on a liver-mimicking gel phantom. RESULTS: Less than 30% attenuation through the Kapton film was verified. Shadowing behind the copper tracks was observed in air and the measured radial irradiation correlated well with the diffraction pattern calculated numerically using the Huygens-Fresnel principle. Both optical experiments and simulations, demonstrate that shadowing is mitigated by the scattering properties of a turbid medium. The microcoil derived thermal maps at the end of a Nd:YAG laser ablation performed on a gel phantom in a 3 T scanner confirm that the modified irradiation pattern does not disrupt the thermal symmetry, even though, unlike tissue, the gel is minimally scattering. CONCLUSIONS: The results from this initial assessment indicate that microcoils can be safely integrated with ablation catheters and ensure that the complete necrosis of the liver tumor can still be achieved.

Magnetic Resonance Imaging Duodenoscope.

A side-viewing duodenoscope capable of both optical and magnetic resonance imaging (MRI) is described. The instrument is constructed from MR-compatible materials and combines a coherent fiber bundle for optical imaging, an irrigation channel and a side-opening biopsy channel for the passage of catheter tools with a tip saddle coil for radio-frequency signal reception. The receiver coil is magnetically coupled to an internal pickup coil to provide intrinsic safety. Impedance matching is achieved using a mechanically variable mutual inductance, and active decoupling by PIN-diode switching. (1)H MRI of phantoms and ex vivo porcine liver specimens was carried out at 1.5 T. An MRI field-of-view appropriate for use during endoscopic retrograde cholangiopancreatography (ERCP) was obtained, with limited artefacts, and a signal-to-noise ratio advantage over a surface array coil was demonstrated.

Magneto-inductive catheter receiver for magnetic resonance imaging.

A catheter-based RF receiver for internal magnetic resonance imaging is demonstrated. The device consists of a double-sided thin-film circuit, wrapped around a hollow catheter and sealed in place with heat-shrink tubing. Signals are detected using a resonant LC circuit at the catheter tip and transmitted along the catheter using an array of coupled LC circuits arranged as a magneto-inductive waveguide, a form of low frequency metamaterial. Coupling to a conventional RF system is accomplished using a demountable inductive transducer. Protection against external B 1 and E fields is obtained by using figure-of-eight elements with an electrical length shorter than that of an immersed dipole. The system is primarily designed for biliary imaging, can pass the biopsy channel of a side-opening duodenoscope, and is guidewire-compatible, potentially allowing clinicians to implement MR image guided procedures without changing their standard practice. Decoupling against B 1 and E fields is verified, and in vitro (1)H magnetic resonance imaging with submillimeter resolution is demonstrated at 1.5 T using phantoms.

Anterior cervical discectomy and fusion in the ovine model.

Anterior cervical discectomy and fusion (ACDF) is the most common surgical operation for cervical radiculopathy and/or myelopathy in patients who have failed conservative treatment. Since the operation was first described by Cloward and Smith and Robinson in 1958, a variety refinements in technique, graft material and implants have been made. In particular, there is a need for safe osteoinductive agents that could benefit selected patients. The ovine model has been shown to have anatomical, biomechanical, bone density and radiological properties that are similar to the human counterpart, the most similar level being C3/4. It is therefore an ideal model in which preclinical studies can be performed. In particular this methodology may be useful to researchers interested in evaluating different devices and biologics, including stem cells, for potential application in human spinal surgery.

In vivo 31P magnetic resonance spectroscopy using a needle microcoil.

Batch fabrication methods have been used to produce low-cost microcoils for magnetic resonance spectroscopy (MRS) that could be discarded after applications such as insertion into tissue during interventional surgery. Needle-shaped microcoils were constructed using electroplated conductors buried in shafts formed with different combinations of silicon and plastic and used to acquire in vivo (31)P spectra of rat thigh muscle at 81 MHz. The designs in this study achieved a maximum signal-to-noise ratio (SNR) for phosphocreatine (PCr) of 10.4 in a 10-min acquisition, with the three adenosine triphosphate (ATP) multiplets also clearly visible. An average 20% reduction in PCr occurred over a 60-min period, and intracellular pH was estimated to be 6.6, which are both evidence of ischemia. A needle microcoil design could have applications in real-time MRS of tumors or in evaluating pathology in general during surgical investigations.

Magnetic resonance imaging with ultrashort TE (UTE) PULSE sequences: technical considerations.

It is now possible to detect signals from tissues and tissue components with short T(2)s, such as cortical bone, using ultrashort TE (UTE) pulse sequences. The background to the use of these sequences is reviewed with particular emphasis on MR system issues. Tissue properties are discussed, and tissues are divided into those with a majority and those with a minority of short T(2) components. UTE pulse sequences and their variants are described and clinical applications are illustrated. System design requirements for sequences of this type, including gradient performance, RF switching, and data-processing issues, are outlined.