RESUMO
We report the case histories of 7 human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) who had a diagnosis of Castleman disease. All 6 patients who were treated responded to chemotherapy; immune reconstitution was observed in 5 patients, but it did not prevent relapse of Castleman disease. However, the mean duration of survival observed in this series (48 months) was most probably due to immune reconstitution resulting from receipt of HAART, which reduced the mortality associated with HIV disease.
Assuntos
Hiperplasia do Linfonodo Gigante/etiologia , Infecções por HIV/tratamento farmacológico , Infecções por Herpesviridae/etiologia , Herpesvirus Humano 8 , Adulto , Terapia Antirretroviral de Alta Atividade , Hiperplasia do Linfonodo Gigante/mortalidade , Infecções por HIV/complicações , Infecções por HIV/imunologia , Infecções por HIV/mortalidade , Infecções por Herpesviridae/mortalidade , Herpesvirus Humano 8/imunologia , Herpesvirus Humano 8/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Análise de SobrevidaRESUMO
A 34-year-old man with human immunodeficiency virus type 1 (HIV-1) presented with axial rigidity, painful spasms, and delayed hemiparesis and dementia. Cerebrospinal fluid analysis showed no antiglutamic acid dehydrogenase antibodies but viral genome from Epstein-Barr virus was detected by polymerase chain reaction. Clinical features and possible viral aetiology of progressive encephalomyelitis with rigidity are briefly discussed.
