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1.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-793282

RESUMO

Objective To investigate the expression pattern of linc00346 and E2F2, and its prognostic value on liver cancer. Methods Gene expression profile data of patients with liver cancer was downloaded from the cancer genome atlas (TCGA) database. Paired t test was used to evaluate the differential expression of linc00346 and E2F2 from tissues and matched adjacent normal tissues. Co-expression analysis of linc00346 and E2F2 was performed using Pearson correlation. Log-Rank test and Cox proportional hazards regression were used to estimate prognostic value of linc00346 and E2F2. Results linc00346 and E2F2 expression were upregulated in liver cancer tissue specimens (all P<0.05), and fold change was 2.24 and 3.72, respectively. Pearson coefficient was 0.20 (P<0.001). Patient with linc00346 and E2F2 high expression had a 1.77 (95 % CI: 1.23-2.55) and 2.19 (95 % CI: 1.51-3.17) times higher hazard of death than those with linc00346 and E2F2 low expression, respectively. However, only E2F2 was significantly associated with the prognosis of liver cancer in multiple Cox regression. Conclusions linc00346 and E2F2 expressions are upregulated in liver cancer tissues, and patients with linc00346 and E2F2 high expressions has poor prognosis. It is of great significance to discover linc00346 and E2F2 as a novel therapeutic target for liver cancer.

2.
Front Microbiol ; 6: 147, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25759689

RESUMO

It is unknown whether MIRU-VNTR (Mycobacterial Interspersed Repetitive Unit-Variable Number of Tandem Repeat) is associated with drug resistance of Mycobacterium tuberculosis. The purpose of this study was to explore the ability of 24 MIRU loci to predict the drug resistance of Isoniazid (INH), Rifampicin (RFP), Streptomycin (SM), Ethambutol (EMB) and Pyrazinamide (PZA). We collected the drug resistance and MIRU loci information of 109 strains of M. tuberculosis from an open database. The results of multivariate logistic regression showed that the VNTR polymorphism of MTUB04 was related to INH resistance [odds ratio (OR) = 2.82, P = 0.00], RFP resistance (OR = 1.91, P = 0.02), SM resistance (OR = 1.98, P = 0.01) and EMB resistance (OR = 1.95, P = 0.03). MIRU40 was associated with INH resistance (OR = 2.22, P = 0.00). MTUB21 was connected with INH resistance (OR = 1.63, P = 0.02) and SM resistance (OR = 1.69, P = 0.01). MIRU26 was correlated with SM resistance (OR = 1.52, P = 0.04). MIRU39 was associated with EMB resistance (OR = 4.07, P = 0.02). The prediction power of MIRU loci were 0.84, 0.70, 0.85, and 0.74 respectively for INH (predicted by MTUB04, MIRU20, and MTUB21), RFP (predicted by MTUB04), SM (predicted by MTUB21 and MIRU26) and EMB (MTUB04 and MIRU39) through ROC analysis. Our results showed that MIRU loci were related to anti-tuberculosis drug and could predict the drug resistance of tuberculosis.

3.
Appl Biochem Biotechnol ; 168(1): 174-82, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21976150

RESUMO

Mesoporous materials possess a hexagonal array of uniform mesopores, high surface areas, and moderate acidity. They are one of the important catalysts in the field of catalytic pyrolysis. In this paper, mesoporous materials of Al-MCM-41, La-Al-MCM-41, and Ce-Al-MCM-41 were synthesized, characterized, and tested as catalysts in the cellulose catalytic pyrolysis process using a fixed bed pyrolysis reactor. The results showed that mesoporous materials exhibited a strong influence on the pyrolytic behavior of cellulose. The presence of these mesoporous molecular sieve catalysts could vary the yield of products, which was that they could decrease the yield of liquid and char and increase the yield of gas product, and could promote high-carbon chain compounds to break into low-carbon chain compounds. Mesoporous molecular sieve catalysts were benefit to the reaction of dehydrogenation and deoxidation and the breakdown of carbon chain. Further, La-Al-MCM-41 and Ce-Al-MCM-41 catalysts can produce more toluene and 2-methoxy-phenol, as compared to the non-catalytic runs.


Assuntos
Biocombustíveis/análise , Biotecnologia/métodos , Celulose/metabolismo , Óleos de Plantas/metabolismo , Temperatura , Adsorção , Catálise , Hidrólise , Nitrogênio/química , Porosidade , Propriedades de Superfície , Difração de Raios X
4.
Chinese Medical Journal ; (24): 537-540, 2011.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-241561

RESUMO

<p><b>BACKGROUND</b>Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS)-related stigma is an obstacle to the implementation of treatment, care, and support programs for people living with HIV/AIDS. This study explored the association of the HIV knowledge with the attitudes toward HIV/AIDS.</p><p><b>METHODS</b>A cross-sectional survey was conducted in HIV epidemic rural areas with 5355 participants. Their knowledge and attitudes about HIV/AIDS were assessed, and the associations of HIV transmission and non-transmission knowledge with negative attitudes towards the HIV/AIDS were analyzed.</p><p><b>RESULTS</b>Negative attitudes were significantly correlated with the HIV non-transmission knowledge and the correlation was higher than that with HIV transmission knowledge among participants who were male, 20 years old and migrant workers, students and respondents of and above junior high school. However, among those who were female, age 30 and older, illiterate with primary school education, negative attitudes were significantly associated with HIV non-transmission knowledge and the association was lower than that with HIV transmission knowledge.</p><p><b>CONCLUSIONS</b>HIV transmission knowledge and non-transmission knowledge have different influences on negative attitudes towards HIV/AIDS among different demographic subgroups.</p>


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Síndrome da Imunodeficiência Adquirida , Estudos Transversais , Infecções por HIV , Conhecimentos, Atitudes e Prática em Saúde , Fatores Socioeconômicos , Inquéritos e Questionários
5.
Zhonghua Zhong Liu Za Zhi ; 27(9): 565-6, 2005 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-16438859

RESUMO

OBJECTIVE: To investigate the diagnostic value of dual-head (18)F-fluorodeoxyglucose ((18)F-FDG) imaging in metastatic lesion with unknown primary tumour (UPT). METHODS: Seventy patients with UPT underwent dual-head (18)F-FDG imaging after iv (18)F-FDG 1.85 MBq/kg. The primary tumour was diagnosed according to the FDG uptake and T/N value. RESULTS: Of the 70 patients, the primary tumour was identified by positive FDG imaging and finally confirmed pathologically in 58 patients (82.9%), and 12 patients had a negative FDG imaging (17.1%). Forty-two of the 58 positive patients were found to have lung cancer (72.4%). Among the 12 negative patients, their primary tumour was then identified by other diagnostic procedures in 5 patients (41.7%), in 1 patient, the primary site was detected during follow-up, however, the primary tumour was never detected in the rest 6 patients. CONCLUSION: Dual-probe (18)F-FDG imaging is a simple, quick, non-invasive and sensitive technique with an accuracy over 80% in the diagnosis of unknown primary tumour. The lung is found to be the most frequent primary site. Dual-probe (18)F-FDG imaging can be recommended as the first diagnostic choice for UPT.


Assuntos
Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico por imagem , Linfonodos/diagnóstico por imagem , Neoplasias Primárias Desconhecidas/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Feminino , Humanos , Neoplasias Pulmonares/patologia , Linfonodos/patologia , Metástase Linfática , Masculino , Neoplasias Primárias Desconhecidas/patologia
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