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1.
Langmuir ; 40(24): 12322-12342, 2024 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-38830755

RESUMO

Silicon carbide, as a third-generation semiconductor material, plays a pivotal role in various advanced technological applications. Its exceptional stability under extreme conditions has garnered a significant amount of attention. These superior characteristics make silicon carbide an ideal candidate material for high-frequency, high-power electronic devices and applications in harsh environments. In particular, corrosion resistance in natural or artificially acidic and alkaline environments limits the practical application of many other materials. In fields such as chemical engineering, energy conversion, and environmental engineering, materials often face severe chemical erosion, necessitating materials with excellent chemical stability as foundational materials, carriers, or reaction media. Silicon carbide exhibits outstanding performance under these conditions, demonstrating significant resistance to corrosive substances such as hydrochloric acid, sulfuric acid, nitric acid, and alkaline substances such as potassium hydroxide and sodium hydroxide. Despite the well-known chemical stability of silicon carbide, the stability conditions of its different types (such as 3C-, 4H-, and 6H-SiC polycrystals) in acidic and alkaline environments, as well as the specific corrosion mechanisms and differences, warrant further investigation. This Review not only delves deeply into the detailed studies related to this topic but also highlights the current applications of different silicon carbide polycrystals in chemical reaction systems, energy conversion equipment, and recycling processes. Through a comprehensive analysis, this Review aims to bridge research gaps, offering a comparative analysis of the advantages and disadvantages between different polymorphs. It provides material scientists, engineers, and developers with a thorough understanding of silicon carbide's behavior in various chemical environments. This work will propel the research and development of silicon carbide materials under extreme conditions, especially in areas where chemical stability is crucial for device performance and durability. It lays a solid foundation for ultra-high-power, high-integration, high-reliability module architectures, supercomputing chips, and highly safe long-life batteries.

2.
Front Psychiatry ; 15: 1386321, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38807690

RESUMO

Intense interest surrounds current research on psychedelics, particularly regarding their potential in treating mental health disorders. Various studies suggest a link between the subjective effects produced by psychedelics and their therapeutic efficacy. Neuroimaging evidence indicates an association of changes in brain functional connectivity with the subjective effects of psychedelics. We conducted a review focusing on psychedelics and brain functional connectivity. The review focused on four psychedelic drugs: ayahuasca, psilocybin and LSD, and the entactogen MDMA. We conducted searches in databases of MEDLINE, Embase, APA PsycInfo and Scopus from inception to Jun 2023 by keywords related to functional connectivity and psychedelics. Using the PRISMA framework, we selected 24 articles from an initial pool of 492 for analysis. This scoping review and analysis investigated the effects of psychedelics on subjective experiences and brain functional connectivity in healthy individuals. The studies quantified subjective effects through psychometric scales, revealing significant experiences of altered consciousness, mood elevation, and mystical experiences induced by psychedelics. Neuroimaging results indicated alterations in the functional connectivity of psychedelics, with consistent findings across substances of decreased connectivity within the default mode network and increased sensory and thalamocortical connectivity. Correlations between these neurophysiological changes and subjective experiences were noted, suggesting a brain network basis of the psychedelics' neuropsychological impact. While the result of the review provides a potential neural mechanism of the subjective effects of psychedelics, direct clinical evidence is needed to advance their clinical outcomes. Our research serves as a foundation for further exploration of the therapeutic potential of psychedelics.

3.
Comput Intell Neurosci ; 2022: 1427219, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36093499

RESUMO

For the problems of unreasonable computation offloading and uneven resource allocation in Mobile Edge Computing (MEC), this paper proposes a task offloading and resource allocation strategy based on deep learning for MEC. Firstly, in the multiuser multiserver MEC environment, a new objective function is designed by combining calculation model and communication model in the system, which can shorten the completion time of all computing tasks and minimize the energy consumption of all terminal devices under delay constraints. Then, based on the multiagent reinforcement learning system, system benefits and resource consumption are designed as rewards and losses in deep reinforcement learning. Dueling-DQN algorithm is used to solve the system problem model for obtaining resource allocation method with the highest reward. Finally, the experimental results show that when the learning rate is 0.001 and discount factor is 0.90, the performance of proposed strategy is the best. Furthermore, the proportions of reducing energy consumption and shortening completion time are 52.18% and 34.72%, respectively, which are better than other comparison strategies in terms of calculation amount and energy saving.


Assuntos
Aprendizado Profundo , Algoritmos , Reforço Psicológico , Alocação de Recursos
4.
Opt Lett ; 46(17): 4398-4401, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34470025

RESUMO

Recently, terahertz (THz)-driven particle accelerators have drawn increasing attention. The development of high-energy-gain THz accelerators on chip has been a challenge. Here we propose a concept of an on-chip THz-driven particle accelerator that uses few-cycle THz pulses to drive dielectric prisms. It avoids the serious waveguide dispersion of previous THz linacs based on dielectric lined waveguides and enhances the electron-energy gain. In addition, we propose to use prism stacks to overcome the asynchronization effect when accelerating low-energy particles, by which a longer acceleration length with even higher energy gain can be realized. Compared with the available on-chip dielectric laser accelerators, the proposed scheme avoids serious dielectric dispersion and enhances accelerated bunch charge. Hence, it promises an attractive particle accelerator on chip.

5.
Front Behav Neurosci ; 15: 637678, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33897386

RESUMO

Attachment insecurity in the forms of attachment anxiety and avoidance is associated with mental disorders in humans. In this research field, rodents, especially mice and rats, are commonly used to study social behaviors and underlying biological mechanisms due to their pronounced sociability. However, quantitative assessment of attachment security/insecurity in rodents has been a major challenge. The present study identified attachment insecurity behaviors in rats subjected to maternal separation (MS) during postnatal days (PD) 2-16 and early weaning (EW) during PD 17-21. This MSEW procedure has been used to mimic early life neglect in humans. After MSEW, rats continued to survive until early adulthood when they were subjected to open-field, social interaction, and elevated-plus maze tests. Compared to CNT rats in either gender, MSEW rats moved longer distances at higher velocities in the open-field. The MSEW rats also showed lower ratios of travel distance at central zone over that on whole arena of the open-field compared to CNT rats. In social interaction test, male CNT rats preferred to investigate an empty cage than females; whereas female CNT rats spent more time with a partner-containing cage as compared to males. This gender-specific difference was reversed in MSEW rats. On elevated-plus maze female CNT rats exhibited more risk-taking behaviors as compared to male counterparts. Moreover, female MSEW rats experienced a greater difficulty in making a decision on whether approaching to or averting from which arms of elevated-plus maze. Taken together, male MSEW rats behaved like attachment anxiety while females' phenotype is alike to attachment avoidance described in humans. These results shall prompt further application of MSEW rat in abnormal psychology and biological psychiatry research.

6.
Front Neuroanat ; 14: 30, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32581731

RESUMO

Cuprizone (CPZ) is a chemical chelator toxic to mitochondria of cells. While inducing oligodendrocyte (OL) loss and demyelination, CPZ caused no fatal damage to the other brain cells (neurons, astrocytes, and microglia) in previous studies, suggesting differential susceptibility and vulnerability of brain cells to the CPZ intoxication. To demonstrate this interpretation, C57BL/6 mice were fed rodent chow without or with CPZ (0.2%, w/w) for 7 days. One day later, mitochondrial function of brain cells was assessed by proton magnetic resonance spectroscopy (1H-MRS) and biochemical analysis. Another batch of mice were processed to localize the CPZ-induced damage to mitochondrial DNA, label brain cells, and identify apoptotic cells. Compared to controls, CPZ-exposed mice showed significantly lower levels of N-acetyl-L-aspartate, phosphocreatine, and ATP detected by 1H-MRS, indicating mitochondrial dysfunction in brain cells. Susceptibility analysis showed an order of OLs, microglia, and astrocytes from high to low, in terms of the proportion of 8-OHdG labeled cells in each type of these cells in corpus callosum. Vulnerability analysis showed the highest proportion of caspase-3 positive cells in labeled OLs in cerebral cortex and hippocampus, where neurons showed no caspase-3 labeling, but the highest proportion of 8-OHdG labeling, indicating a lowest vulnerability but highest susceptibility to CPZ-induced mitochondrial dysfunction. Immature OLs, microglia, and astrocytes showed adaptive changes in proliferation and activation in response to CPZ-exposure. These data for the first time demonstrated the CPZ-induced mitochondria dysfunction in brain cells of living mouse and specified the differential susceptibility and vulnerability of brain cells to the CPZ intoxication.

7.
Opt Express ; 28(7): 9501-9509, 2020 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-32225556

RESUMO

We illustrate the transformation of terahertz plasmonics within an array of rectangular sub-wavelength holes (RSHs) into coherent and enhanced terahertz emission via Smith-Purcell effect. The radiative plasmonic modes within each RSH of the array are successively excited by an free-electron beam, which then generate coherent radiation by constructive interference. Compared with the case without taking plasmonics into consideration, the radiation field intensity is enhanced by more than an order of magnitude, affording a promising way of developing high-power terahertz radiation. We perform detailed analysis of the plasmonic modes within the RSH by using the dielectric waveguide theory, and the results are verified by numerical simulations. The influences of the RSH parameters on the radiation properties are revealed and discussed.

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