Changes of biochemical indexes and proteinuria levels in elderly patients with cerebral small vessel disease / 解放军医学杂志

Objective: To observe the characteristics in changes of cystatin C (Cys C), total cholesterol (TC), lipoprotein a [Lp(a)] and proteinuria levels and their significance in patients with cerebral small vessel disease (CSVD). Methods: This was a retrospective study consecutively recruiting 316 patients with CSVD from September 2016 to August 2018 at Lanzhou University Second Hospital, including 113 with white matter hyperintensity (WMH), 101 with lacunar infarction (LI) and 102 with cerebral microbleeds (CMB). One hundred and two elderly people without abnormal head MRI changes and positive signs of nervous system were selected as the control group. Cys C, TC, Lp(a) and proteinuria levels were measured and compared between the groups. Results: Serum Cys C and proteinuria levels in CSVD group [(0.9 ± 0.2) mg/L, 99(31.2%)] were all significantly higher than those in control group [(0.8 ± 0.2) mg/L, 12(11.8%), P<0.05]. While, serum TC levels in CSVD group [(3.9 ± 1.0) mmol/L] was significantly lower than those in control group (P<0.05). Subgroup analysis showed that serum Cys C and proteinuria levels in the WMH group [(0.9 ± 0.2) mg/L, 33(29.2%), respectively], the LI group [(0.9 ± 0.2) mg/L, 36(35.6%), respectively] and the CMB group [(0.9 ± 0.1) mg/L, 30(29.4%), respectively] were significantly higher than those in control group (P<0.05). While, serum TC level s in WMH group, LI group and CMB group [(3.9±1.1) mmol/L, (3.9±1.0) mmol/L, (3.8±0.8) mmol/L, respect ively] were significantly lower than those in control group (P<0.05). After adjustment for confounding factors, multiple logistic regression analysis showed that Cys C and proteinuria were independent risk factors for CSVD (P<0.05). Additionally, subgroup analysis showed that TC was independent protective factor for CMB (P<0.05), Lp(a) was independent risk factor for LI (P<0.05). Conclusions: Cys C, Lp(a) and proteinuria may be risk factors for CSVD, but may not carry the same weight for WMH, LI and CMB. Meanwhile, TC is an independent protective factor for CMB.

Exploration of the association of H. pylori and EBV infection with cardiac and distal gastric adenocarcinoma among residents in Cixian County, a high-risk area of esophgeal cancer in Hebei province / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To evaluate the H. pylori and Epstein-Barr virus infection in cardiac and distal gastric adenocarcinoma tissues in residents in Cixian county, a high risk area of esophageal cancer in Hebei province, and to explore the putative role of H. pylori and Epstein-Barr virus infection in the carcinogenesis of adenocarcinoma at different subsites of stomach.</p><p><b>METHODS</b>H. pylori and Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) immunopositivities were determined by Elivision(TM) plus immunohistochemical staining in 190 gastric adenocarcinoma tissues including 144 cases of cardiac adenocarcinoma and 46 cases of distal gastric adenocarcinoma. The relationship between H. pylori and Epstein-Barr virus infection and the subsite, Laurén type as well as other clinicopathological features of gastric adenocarcinoma were analyzed.</p><p><b>RESULTS</b>No significant difference was found between the H. pylori detection rates in cardiac and distal gastric adenocarcinomas(56.9% vs. 65.2%, P > 0.05). The detection rate of H. pylori in intestinal type was significantly higher than that in the diffuse type distal gastric adenocarcinomas (71.8% vs. 28.6%, P < 0.05). No positive expression of EBV-LMP1 was found in the gastric adenocarcinomas in this study.</p><p><b>CONCLUSIONS</b>No significant differences in H. pylori and EBV-LMP1 infections were found between cardiac and distal gastric adenocarcinomas in Cixian county. H. pylori infection is related with the intestinal type of distal gastric adenocarcinoma.</p>

The establishment of testicular fibrosis model in Wistar rats / 中华男科学杂志

<p><b>OBJECTIVES</b>To establish the testicular fibrosis model in rats.</p><p><b>METHODS</b>Wistar rats were divided into control group(n = 12) and model group(n = 40) randomly. Testicular fibrosis model was built with the classical method of establishing experimental autoimmune orchitis (EAO) combined with injecting Bacille Calmette-Guerin (BCG) into left testis.</p><p><b>RESULTS</b>The incidence rate of EAO and the rate of testicular fibrosis were 100%, 11.1% and 100%, 81.5% at 80, 140 days after the first infection, respectively.</p><p><b>CONCLUSIONS</b>The model of rat testicular fibrosis was established successfully.</p>