1.
Org Lett
; 25(16): 2939-2943, 2023 04 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37078609
RESUMO
We report a new serine/threonine ligation (STL)-assisted diaminodiacid (DADA) strategy for the flexible construction of disulfide surrogates by the option of more abundant -Aa-Ser/Thr- ligation sites. The practicality of this strategy was evidenced by the synthesis of the intrachain disulfide surrogate of C-type natriuretic peptide and the interchain disulfide surrogate of insulin.