Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction.

A series of 1,5-benzothiazepine derivatives were synthesized by the reaction of 1,5-benzothiazepine containing 2-phenoxy-quinoline with benzohydroximinoyl chlorides and hydrazonoyl chlorides at room temperature. The structures of these novel compounds were confirmed by spectrum, elemental, and X-ray crystallographic analysis.