Investigation of the infection status in patients with vitiligo / 国际检验医学杂志

Objective To investigate the infection status in patients with vitiligo.Methods A total of 434 patients with vitiligo were collected eligible data by a uniform questionnaire.Anti-HEV IgG and anti-HEV IgM were detected by enzyme-linked immunosorbent assay(ELISA).The correlation between the positive rate of anti-HEV IgG and sex,age,duration and immunology in-dex were analyzed.Results Out of the 434 patients,26.26％ of the total subjects were anti-HEV IgG positive.The positivity of anti-HEV IgG in adults and the progress of vitiligo patients was higher than that of teenagers and stabilization of vitiligo patients,the difference was statistically significant(P<0.05).Compared to the normal cases of IgA,IgG,C4,the positivity of anti-HEV IgG was significantly higher in the abnormal cases,the difference was statistically significant(P<0.05).Those 10 cases who were anti-HEV IgM positive,were anti-HEV IgG positive also.Conclusion The infection status in patients with vitiligo is serious and effective prevention strategies are required in future for reducing HEV transmission in these patients in order to reduce the incidence.

Pediatric Patients with Vitiligo in Eastern China: Abnormalities in 145 Cases Based on Thyroid Function Tests and Immunological Findings.

BACKGROUND: The aim of this study was to evaluate abnormalities in thyroid function according to tests and the humoral immune systems of patients from Eastern China with pediatric vitiligo. MATERIAL AND METHODS: A total of 145 pediatric patients with vitiligo were investigated in this study, along with 59 children without autoimmune diseases as controls. Laboratory tests of thyroid function were conducted, and these tests examined free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TG-Ab), thyroid peroxidase antibody (TPO-Ab), antinuclear antibodies (ANAs), immunoglobulins (IgA, IgM, and IgG), and complements (C3 and C4). RESULTS: A total of 63 patients (43.4%), including 39 boys (44.3%) and 24 girls (42.1%), displayed abnormalities in thyroid function according to the tests. This finding indicated that patients with vitiligo differed significantly from those in the control group (P<0.001), particularly in terms of FT3 and TSH abnormalities (P<0.05). However, these groups did not deviate significantly with respect to FT4, Tg-Ab, and TPO-Ab abnormalities (P>0.05). Thirteen patients (8.9%) and 1 (1.7%) control were positive for ANA. All 12 specific antibodies were detected in 8 patients. Anti-SSA/Ro-60 and anti-SSA/Ro-52 were the most prevalent antibodies, followed by anti-dsDNA and then by anti-SmD1 and CENB-P. The serum levels of IgA and IgG decreased more significantly in the vitiligo group than in the control group (P<0.001). However, no significant difference was observed in terms of IgM levels (P>0.05). C4 serum levels also decreased more significantly in the vitiligo group than in the control group (P=0.035). CONCLUSIONS: Results suggest that the incidence of abnormalities in the thyroid functions of children and adolescents is significantly higher in those with vitiligo than that in those in the control group. In addition, immunological dysfunction is common in the vitiligo group.

Relationship between vitiligo and thyroid diseases / 国际检验医学杂志

Objective To investigate the relationship between vitiligo and thyroid diseases .Methods Chemiluminescence was used to detect serum levels of free triiodothyronine (FT3) ,free thyroxine(FT4) ,thyrotropic stimulating hormone(TSH) ,anti‐thy‐roglobulin antibody(TG‐Ab) and anti‐thyroperoxidase antibody(TPO‐Ab) in 289 vitiligo patients and 128 healthy subjects .All re‐sults were statistically analyzed .Results The abnormal rates of FT3 ,TG‐Ab and TPO‐Ab in vitiligo patients were higher than healthy subjects (P<0 .05) ,which might be correlated with the age and gender of vilitigo patients .Conclusion Levels of thyroid function and autoantibody might be abnormal in vilitigo patients ,which could be more obvious in male and adolescent patients .It could be advantageous to screen thyroid function and antibody levels in patients with vitiligo .