RESUMO
Acute pancreatitis is rarely seen in children, and it is often drug induced. Valproic acid (VPA) is one of the most widely used anticonvulsants for children all over the world. We present 11-year-old boy developing pancreatitis after 6 months of therapy with VPA. The symptoms of pancreatitis subsided within 2 weeks after discontinuation of VPA. It seems that the prognosis of VPA-associated acute pancreatitis depends on early diagnosis, timely withdrawal of the offending agent and the treatment.
Assuntos
Anticonvulsivantes/efeitos adversos , Hemorragia/induzido quimicamente , Pancreatite/induzido quimicamente , Ácido Valproico/efeitos adversos , Doença Aguda , Anticonvulsivantes/uso terapêutico , Criança , Epilepsia Generalizada/complicações , Epilepsia Generalizada/tratamento farmacológico , Hemorragia/patologia , Humanos , Deficiência Intelectual/complicações , Laparotomia , Masculino , Pancreatite/patologia , Ácido Valproico/uso terapêuticoRESUMO
Transverse white nail banding can be inherited or caused by various diseases and medications, including cancer chemotherapeutic agents, retinoids, tetracyclines, antimalarials, sulfonamides, pilocarpine, cortisone and zidovudine. Neither a specific drug nor classes of cancer chemotherapeutics were associated more frequently than the other with acquired transverse leukonychia in patients with cancer. Here we report transverse leukonychia in four children with cancer receiving different chemotherapeutic agents.
