Experimental study of 99Tc m-3PRGD 2 targeted receptor imaging on angiogenesis in rheumatoid arthritis / 中华核医学与分子影像杂志

Objective:To investigate the feasibility of 99Tc m-hydrazinonicotinamide-(poly-(ethylene glycol)) 4-E[(poly-(ethylene glycol))4-c((Arg-Gly-Asp)fK)] 2 (3PRGD 2) in the early diagnosis of rheumatoid arthritis (RA). Methods:Sixty female Wistar rats were divided into control group ( n=10; injected with saline of 0.3 ml/piece) and collagen-induced arthritis (CIA) group ( n=50; injected with type Ⅱ collagen emulsion of 0.3 ml/piece). Rats in 2 groups were subjected to 99Tc m-3PRGD 2 planar imaging before modeling, 25 and 45 d after modeling. The changes of the target/non-target ratio (T/NT) of the lesion joint and mediastinum before and after modeling were measured and analyzed in CIA rats, and compared with rats in control group. Pathological examination was conducted. Repeated measures analysis of variance and independent-sample t test were used to analyze the data. Results:Thirty-two rats in CIA group were successfully established, and obvious synovitis and synovial thickening, neovascularization were observed in the images. The T/NT of diseased joints in CIA group before modeling, 25 and 45 d after modeling were 0.158±0.023, 0.402±0.144, and 0.705±0.163 ( F=286.924, P<0.01). The T/NT of diseased joints at 25 and 45 d after modeling were significantly different from those of control group (0.160±0.028 and 0.158±0.032; t values: -10.484 and -20.917, both P<0.01). Immunohistochemistry results showed positive expressions of vascular endothelial growth factor, α vβ 3 and tumor necrosis factor-α in the synovial tissue in of diseased joints in rats of CIA group. Conclusion:99Tc m-3PRGD 2 has high sensitivity for joint synovial neovascularization in rat rheumatoid arthritis models and is expected to be used for early diagnosis of RA.

Superior border of the arcuate line: Three dimension reconstruction and digital measurements of the fixation route for pelvic and acetabular fractures.

PURPOSE: To obtain a series of parameters describing the shape and bone thickness of the fixation route along the superior border of the arcuate line, so as to provide references for pelvic and acetabular surgery and design pelvic anatomic internal fixators. METHOD: A total of 175 complete pelvic computed tomography (CT) scans of normal adult pelvises were collected. Each person's CT scans were reconstructed to create a three-dimensional pelvic model. A curve of the fixation route was delineated and divided into 11 equal parts. The total length of the curve, the radius of curvature, and the bone thickness at each decile point were all measured. The position of the pelvic inlet, the anterior and posterior sagittal diameter were measured. RESULTS: The radius of curvature at each decile point were 29.18 ± 15.53, 55.27 ± 29.48, 43.04 ± 14.42, 59.62 ± 21.02, 91.67 ± 52.01, 78.9 ± 38.66, 75.76 ± 25.87, 61.75 ± 16.68, 54.62 ± 14.88, and 43.61 ± 19.10 mm, respectively. The anterior and posterior sagittal diameter of the pelvic inlet was 66.01 ± 9.15 and 41.36 ± 8.19 mm, respectively. For all groups divided by the ratio of the posterior and the anterior sagittal diameter, the decile points 1, 3, and 10 had smaller radii of curvature than the before and after points, respectively. CONCLUSIONS: The curve of the fixation route along superior border of arcuate line has a relatively greater bending degree at the pubic tubercle, iliopubic eminence and close to the sacroiliac joint. With the transition of the pelvic inlet shape from android to gynecoid and platypelloid type, the bone surface at the iliopubic eminence becomes flatter. Pelvic and acetabular surgery could be more accurate by referring to the previous key bending points and the change of the pelvic inlet shape.

Advances in imaging methods for early diagnosis of rheumatoid arthritis / 中华核医学与分子影像杂志

Rheumatoid arthritis (RA) is a systemic autoimmune disease with unknown etiology.The main feature of RA is chronic,symmetrical and invasive arthritis.RA may present with severe joint deformity and functional loss,which has higher disability and fatality rates.At present,no effective measures can reverse bone damage associated with RA clinically.Therefore,early diagnosis of RA is critical to improve prognosis.In recent years,imaging increasingly plays an important role in the early diagnosis of RA.This article reviews recent advances in imaging methods for early diagnosis of RA.