RESUMO
BACKGROUND: Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. AIM: To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. METHODS: In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. RESULTS: c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. CONCLUSIONS: The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.
Assuntos
Herpesvirus Humano 8/imunologia , Proteínas Proto-Oncogênicas c-kit/metabolismo , Sarcoma de Kaposi/imunologia , Neoplasias Cutâneas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologiaRESUMO
Spinal meningiomas of five or more vertebral segment long are very rare and also less common in younger patients. Under 50 years of age these tumors are more commonly genetical and have worse prognosis. A 25-year-old woman presented with back pain and progressive walking difficulty. An intradural extramedullary tumor extending from thoracal 9th to lumbar 2nd vertebral body was detected. The patient was operated and the tumor was totally removed. The histopathological diagnosis was angiomatous meningioma. Neurological symptoms and signs partially improved postoperatively. Interestingly, magnetic resonance imaging of this patient might easily be confused with ependymoma. Although we performed laminectomy and instrumentation, to maintain stability laminoplasty should be the first treatment modality for such a young patient.
