Two Cases of Ulcerative Colitis with Adjusted Tacrolimus by Daily Therapeutic Drug Monitoring / 日本農村医学会雑誌

It is suggested that in the use of tacrolimus for treatment of ulcerative colitis, it is important to achieve and maintain a high trough level as soon as possible. We examined two cases, with a starting initial dose higher than that recommended in the package insert, and adjusted the dose by daily therapeutic drug monitoring. Improvement of symptoms was observed by maintaining a high trough level of 10 to 15 ng/mL in these 2 cases. This improvement was observed from 9 days after achieving the high trough level, and it took the same number of days as stated in the mode of administration in the package insert.