RESUMO
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.
Assuntos
Mucinas/química , Saliva/metabolismo , Proteínas e Peptídeos Salivares/química , Sequência de Aminoácidos , Sequência de Carboidratos , Glicosilação , Humanos , Dados de Sequência Molecular , Mucina-5B , Mucinas/biossíntese , Oligossacarídeos/química , Peptídeos/química , Estrutura Terciária de Proteína , Proteínas e Peptídeos Salivares/biossíntese , Homologia de Sequência de AminoácidosRESUMO
The IgG, IgA and IgM levels in the serum of 23 patients with maxillofacial bacterial infections were determined. The high IgG level noted on admission further increased in the serum of 14 patients with acute inflammation and decreased in the serum of 10 patients with a chronic course. The level of IgM in the serum of patients with acute inflammation was higher than in the patients with chronic inflammation and decreased in both groups on the 7th day of treatment. The IgA level was high on admission in both groups and fell on the 7th day of treatment. Our results suggest that analysis of the serum level of IgG, IgA and IgM may be of diagnostic and prognostic value in the treatment of maxillofacial bacterial inflammation.
Assuntos
Infecções Bacterianas/imunologia , Necrose da Polpa Dentária/imunologia , Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Doenças Maxilomandibulares/imunologia , Osteomielite/imunologia , Doença Aguda , Adolescente , Adulto , Idoso , Infecções Bacterianas/etiologia , Infecções Bacterianas/terapia , Doença Crônica , Necrose da Polpa Dentária/complicações , Feminino , Humanos , Doenças Maxilomandibulares/etiologia , Doenças Maxilomandibulares/terapia , Masculino , Pessoa de Meia-Idade , Osteomielite/etiologia , Osteomielite/terapia , Prognóstico , Fatores de TempoRESUMO
Analysis of bacteriological examination results in 46 children with submandibular lymph nodes inflammation has been presented in the paper. The examinations have been carried out from the point of view of observation of bacterial flora variation and its drug--resistance. The analysis of examination results has revealed existence of strains such as: S. aureus, S. albus, S. epidermidis. The attention has been called to the necessity of bacterial flora examinations considering substantial changes in the frequency of particular strains occurrence and their drug resistance.
