RESUMO
BACKGROUND: A 12-year-old female western lowland gorilla died in a zoological garden in Germany after exhibiting general neurological signs. METHODS: Balamuthia mandrillaris was identified as causative agent by indirect immunofluorescent staining of brain sections and confirmed by PCR and respective sequencing. RESULTS: The animal suffered from a chronic progressive necrotizing amebic meningoencephalitis. CONCLUSION: This is the first case of Balamuthia amebic encephalitis in Germany.
Assuntos
Amebíase/veterinária , Doenças dos Símios Antropoides/parasitologia , Balamuthia mandrillaris/isolamento & purificação , Encéfalo/patologia , Infecções Protozoárias do Sistema Nervoso Central/veterinária , Gorilla gorilla/parasitologia , Amebíase/diagnóstico , Amebíase/mortalidade , Amebíase/parasitologia , Animais , Doenças dos Símios Antropoides/mortalidade , Encéfalo/parasitologia , Infecções Protozoárias do Sistema Nervoso Central/diagnóstico , Infecções Protozoárias do Sistema Nervoso Central/mortalidade , Infecções Protozoárias do Sistema Nervoso Central/parasitologia , Evolução Fatal , Feminino , Técnica Indireta de Fluorescência para Anticorpo/veterinária , Alemanha , Microscopia de Fluorescência/veterinária , RNA Ribossômico 16S/análiseRESUMO
Literature on spontaneous primary bone tumors in nonhuman primates is sparse. This case report describes 2 different neoplastic bone lesions in 2 adult cynomolgus monkeys (Macaca fascicularis), including macroscopic, radiographic, histologic, and immunohistochemical findings. In one monkey, a firm mass located at the palatogingival junction of the left rostral maxilla was confirmed to be a peripheral ossifying fibroma in light of its histologic and immunohistochemical characteristics. In another monkey, a lobulated tumor at the right distal femur that radiographically showed moderate radiopacity with splotchy areas of mineralization was confirmed to be a juxtacortical chondrosarcoma on histologic examination. The 2 neoplastic bone lesions revealed rare histologic and immunohistochemical characteristics and contribute to the known tumor spectrum of cynomolgus monkeys.
Assuntos
Neoplasias Femorais/veterinária , Fibroma Ossificante/veterinária , Neoplasias Maxilares/veterinária , Doenças dos Macacos/diagnóstico , Osteossarcoma Justacortical/veterinária , Animais , Neoplasias Femorais/diagnóstico por imagem , Neoplasias Femorais/patologia , Fibroma Ossificante/diagnóstico por imagem , Fibroma Ossificante/patologia , Macaca fascicularis , Masculino , Neoplasias Maxilares/diagnóstico por imagem , Neoplasias Maxilares/patologia , Doenças dos Macacos/diagnóstico por imagem , Doenças dos Macacos/patologia , Osteossarcoma Justacortical/diagnóstico por imagem , Osteossarcoma Justacortical/patologia , RadiografiaRESUMO
A uniform cell population of proliferating mast cells with poor cytoplasmic granularity and a few eosinophilic infiltrates was observed in hepatic portal tracts and the cecal submucosa of an adult male cynomolgus macaque (Macaca fascicularis) that was part of a drug safety assessment toxicity study. The proliferating mast cells were positive for Giemsa and toluidine blue staining and had strong immunoreactivity for mast cell tryptase and CD68. Considering size, morphology, immunoreactivity, and distribution of the lesions a benign proliferative disorder of connective tissue mast cells was diagnosed comparable to that seen in indolent systemic mastocytosis in humans, but lacking associated skin lesions. The finding of visceral mast cell proliferation has to be included in the spontaneous background pathology spectrum of cynomolgus macaques used in toxicological studies.
Assuntos
Ceco/patologia , Fígado/patologia , Mastócitos/patologia , Mastocitose Sistêmica/patologia , Animais , Antígenos CD/imunologia , Antígenos de Diferenciação Mielomonocítica/imunologia , Proliferação de Células , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/patologia , Imuno-Histoquímica , Macaca fascicularis , Masculino , Mastócitos/imunologia , Testes de Toxicidade , Triptases/imunologiaRESUMO
BACKGROUND: A 5-year-old female rhesus monkey infected with simian immunodeficiency virus became clinically suspicious with anorexia, increasing weakness and apathy eighty-five weeks after the tonsillar virus inoculation and was euthanised due to a poor prognosis. METHODS AND RESULTS: Postmortal examinations revealed a severe multifocal to coalescing necotizing hepatitis with numerous intranuclear basophilic inclusion bodies. Transmission electron microscopy of the liver resulted in the finding of adenovirus like particles arranged in paracrystalline arrays within the nuclei of hepatocytes. CONCLUSION: The SIV infected rhesus monkey suffered from an adenovirus included necortizing hepatitis, an extremely rare organ manifestation of adenovirus infection in nonhuman primates.
