Studies of the structure and functions of blood cells in senile patients with pneumonia on the biological model of hypoxia by scanning probe microscopy.

Biological model of hypoxia can be used for the diagnosis of functional changes in human erythrocytes under the effect of the hypoxic factor. The use of this model together with modern methods of scanning probe microscopy for evaluation of the severity of pulmonological disease in senile patients will help to predict treatment efficiency and outcome.

[Morphological and mechanical peculiarities of erythrocytes and neutrophils from patients of different age groups with chronic obstructive pulmonary disease and asthma].

Modern scanning probe microscopy methods make possible to study the peculiarities of the cell response in chronic obstructive pulmonary disease and asthma, as well as to diagnose the severity of the diseases which is important in senile age, particularly.

Evaluation of morphometric parameters of native blood cells by atomic force microscopy.

We propose and tested a method for studies of native blood cells by atomic-force microscopy in a humid chamber preserving viability, size, and shape of biological objects. The method has some advantages over scanning in a liquid cell: it allows studying non-fixed blood samples in the form of suspension of live cells and excludes mechanical and chemical influences on the cells.