Intraocular Pressure Spike and Corneal Decompensation Following Selective Laser Trabeculoplasty in Patients With Exfoliation Glaucoma.

PURPOSE: To report 5 cases of intractable intraocular pressure (IOP) elevation and 2 cases of corneal failure in patients with exfoliation glaucoma after undergoing selective laser trabeculoplasty (SLT). METHODS: SLT was performed for the treatment of exfoliation glaucoma in 5 patients, all of whom subsequently developed significant IOP elevation within 1 to 5 weeks following treatment. Two patients went on to develop corneal endothelial failure requiring transplantation within 9 to 11 months. RESULTS: All 5 patients failed to respond adequately to topical antiglaucoma therapy and required trabeculectomy. Two patients required secondary implantation of a glaucoma drainage device. Two patients suffered significant endothelial injury requiring corneal transplantation (one receiving penetrating keratoplasty and another receiving Descemet stripping automated endothelial keratoplasty). CONCLUSIONS: Significant and persistent IOP spikes requiring surgical intervention following SLT are extremely rare, with only 1 other case series of 4 patients (all with heavily pigmented angles) reported in the literature. Exfoliation patients, and likely all patients with heavily pigmented angles, should be considered at higher risk for developing this complication. Corneal endothelial failure is similarly rare. Nine cases have been reported in the literature, none requiring corneal transplantation. Further clinical attention and research is needed to help elucidate what factors (both pressure-dependent and pressure-independent) may predispose patients to corneal changes following SLT.

Trabeculectomy With Mitomycin C or Ahmed Valve Implantation in Eyes With Uveitic Glaucoma.

PURPOSE: To report and compare the results of trabeculectomy with mitomycin C (MMC) and Ahmed valve implantation in the management of uveitic glaucoma. PATIENTS AND METHODS: The records of 41 eyes of 29 patients who underwent trabeculectomy with MMC or Ahmed valve implantation for uveitic glaucoma were retrospectively reviewed. Seventeen eyes underwent trabeculectomy with MMC, and 24 eyes underwent Ahmed valve implantation. Outcomes included postoperative intraocular pressure (IOP), percent reduction from preoperative IOP, postoperative number of medications, time to failure, and complications. RESULTS: Mean follow-up was 21.2 months in the trabeculectomy group and 23.8 months in the valve group (P=0.06). Mean IOP was reduced from 29.2 to 18.4 mm Hg in the trabeculectomy group (31.3%), compared with a reduction from 33.4 to 15.5 mm Hg in the Ahmed valve group (42.7%, P=0.53). Postoperatively, 1.76 medications were used in the trabeculectomy group, compared with 1.83 medications in the Ahmed valve group (P=0.89). Cumulative success at 1 year was 66.7% in the trabeculectomy group, compared with 100% in the Ahmed valve group (P=0.02). Mean time to failure was 8.36 months with trabeculectomy, and 21.8 months with Ahmed valve (P=0.02). Complications in both groups were typically rare and self-limited, with recurrent inflammation being most common. CONCLUSIONS: Although both trabeculectomy with MMC and Ahmed valve implantation are reasonable surgical options in the management of uncontrolled uveitic glaucoma, Ahmed valve implantation was associated with higher cumulative success rate at 1 year and a longer mean time to failure.

Satisfaction and dysphotopsia in the pseudophakic patient.

OBJECTIVE: To examine factors that influence satisfaction after uncomplicated cataract surgery. DESIGN: Retrospective case review and examination of patients. PARTICIPANTS: Sixty-one consecutive patients, seen at the John A. Moran Eye Center, University of Utah School of Medicine, who had uncomplicated cataract surgery from 1 practice and 40 consecutive control patients who met the inclusion criteria and were willing to participate. METHODS: Inclusion criteria were best-corrected visual acuity (BCVA) of at least 20/20, without any ocular disease that might affect vision. Patients were given a complete ophthalmic examination, had photos of the intraocular lens (IOL) and capsule taken, and were asked questions about dysphotopsia and satisfaction. A group of patients >65 years old with 20/20 BCVA and without other ophthalmic diagnoses were recruited, asked the same questions, and compared. RESULTS: The only significant correlation with dissatisfaction was dysphotopsia (r = 0.602, CI 0.42-0.74, p < 0.0001). BCVA, uncorrected visual acuity, posterior capsular opacification, and anterior capsule overlap of the optic were not significantly correlated. The IOL patients were significantly worse for reported glare (p < 0.0001), photophobia (p < 0.0001), and flashes of light (p = 0.0002), but not for halos. CONCLUSIONS: While satisfaction with cataract removal and IOL placement is high, dysphotopsia is the most important contributor to dissatisfaction and is relatively common. Furthermore, these symptoms are much worse than in age-matched controls. Research seeking to ameliorate dysphotopsia is clinically important.

Intraocular pressure change after temporal clear corneal phacoemulsification in normal eyes.

PURPOSE: To evaluate short- and long-term intraocular pressure (IOP) changes after temporal clear corneal phacoemulsification in normal eyes. METHODS: The charts of 266 consecutive non-glaucoma patients who underwent uneventful cataract surgery were reviewed. We recorded preoperative and postoperative (1 day, 1 week, 1 month, 3 months, 6 months, 1 year and 2 years) IOP measurements as well as anatomical properties obtained using Zeiss Humphrey IOL Master (Zeiss Meditech, Dublin, California, USA). RESULTS: Mean IOP reduction after cataract surgery was 8.2%, 4.6%, 6.7% and 7.8% at 3 months, 6 months, 1 year and 2 years, respectively. Lens thickness was the only anatomical characteristic that correlated significantly with IOP decrease after surgery. CONCLUSION: Temporal clear corneal phacoemulsification results in a decrease in postoperative IOP that persists for 2 years following surgery.

Posner-Schlossman syndrome and nonarteritic anterior ischemic optic neuropathy.

A 41-year-old woman with acute OD pain and decreased visual acuity presented with anterior uveitis, an intraocular pressure of 56 mm Hg, an open angle, ipsilateral nerve fiber bundle visual field defects, and optic nerve edema. With control of intraocular pressure and uveitis, visual acuity improved to 20/25, visual field defects persisted, and optic disc pallor developed. She has remained stable over 23 months of follow-up. This case represents a concurrence of glaucomatocyclitic crisis (Posner-Schlossman syndrome, PSS) and nonarteritic ischemic optic neuropathy (NAION). Although this combination occurs rarely, patients with PSS and other risk factors for NAION, including an optic disc that lacks a physiologic cup, should be protected against NAION by prophylactic treatment with ocular antihypertensive medications.