RESUMO
Immunological status was studied in mice born after induction of the graft-versus-host reaction in mothers. The young mice (under 1 month of age) exhibited lymphopenia, prolonged allogeneic skin graft survival, increased susceptibility to infection with typhoid bacteria, decreased number of plaque-forming cells in the spleen after immunization of mice with sheep red blood cells and Vi-antigen. In 2- to 3-month-old mice the analogous changes in immunity and reduced number of T lymphocytes in the spleen and lymph nodes were seen only in those which developed signs of runt-disease. In old mice immunity to sheep erythrocytes and number of T lymphocytes were reduced; however, responses to Vi-antigen were elevated significantly. Most of old-aged mice had high levels of the serum immunoglobulins and transferrins. In some cases positive antiglobulin tests were revealed.
Assuntos
Reação Enxerto-Hospedeiro , Doenças do Sistema Imunitário/congênito , Animais , Feminino , Doenças do Sistema Imunitário/imunologia , Imunidade Celular , Imunização , Linfonodos/imunologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Gravidez , Baço/imunologiaRESUMO
A new procedure is developed for amperometric registration of the equivalence point in iodometric assay of lipid hydroperoxides. The procedure increased accuracy of the analysis. Content of lipid hydroperoxides was calculated by means of a new equation. Concentration of lipid hydroperoxides was studied using the new method both in tissues and blood of intact animals and in those of animals, which were subjected to the effect of high external temperature.