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Blood Coagul Fibrinolysis ; 32(7): 427-433, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34224465

RESUMO

Immune thrombocytopenia is a haematological, autoimmune disorder characterized by elevated platelet demolition due to the presence of antiplatelet autoantibodies derived from B cells and to an irregular, deficient process of platelets production in bone marrow. In this review, after a brief presentation of 'old' strategies used nowadays yet, we focused on new drugs used in the treatment of immune thrombocytopenia and their mechanism of action and posology, basing on the last scientific literature. The observation that CoViD-19 can be associated with immune thrombocytopenia is also put in evidence. Particular attention will be dedicated on the concept that the ideal treatment should represent a solution not only for the failure of normal processes of production and survival of platelets, but also it should improve quality of life of patients, with minimum adverse events. Anyway, despite enormous advances of the last years, further investigations are necessary in order to define scrupulously long-term efficacy of new molecules proposed.


Assuntos
Púrpura Trombocitopênica Idiopática/tratamento farmacológico , Aminopiridinas/uso terapêutico , Anticorpos Monoclonais Humanizados/uso terapêutico , COVID-19/complicações , COVID-19/imunologia , Antígenos de Histocompatibilidade Classe I , Humanos , Imunossupressores/uso terapêutico , Morfolinas/uso terapêutico , Inibidores de Proteínas Quinases/uso terapêutico , Púrpura Trombocitopênica Idiopática/etiologia , Púrpura Trombocitopênica Idiopática/imunologia , Pirimidinas/uso terapêutico , Receptores Fc/antagonistas & inibidores , Receptores de Trombopoetina/agonistas , SARS-CoV-2/imunologia , Quinase Syk/antagonistas & inibidores , Tiazóis/uso terapêutico , Tiofenos/uso terapêutico
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