'It's more than just a running leg': a qualitative study of running-specific prosthesis use by children and youth with lower limb absence.

PURPOSE: The purpose of this study was to investigate the use of running-specific prostheses (RSPs) by children with lower limb absence (LLA) along with the benefits and challenges of RSPs. MATERIALS AND METHODS: In this descriptive qualitative study, eight children (ages 8-20 years) and their parents participated in semi-structured interviews. The interviews were audio-recorded and transcribed. Coded data were the foundation for central theme development. RESULTS: Three main themes were generated. "Run faster, jump higher, do more" (the benefits of RSP use), "Every leg serves its purpose" (comparing functionality between daily use prostheses and RSPs), and "A lot more to think about" (additional considerations with RSP use). CONCLUSIONS: RSPs have a positive impact in promoting children's engagement in sports and physical activities. While some children used their RSP primarily for running, others wore it for a broader range of physical activities. Issues with balance and discomfort caused by leg length discrepancies and/or ill-fitting sockets limited daily wear time. Limitations related to current RSP designs and clinical implementation should be addressed to optimize the functional potential of children with unilateral or bilateral LLA.Implications for rehabilitationRunning-specific prostheses (RSPs) positively impacted children's ability to participate in some sports with peers promoting their physical and social well-being.The main issues that children faced were discomfort, difficulty balancing, and inability to use RSPs for certain sports, while parents' issues focused on supporting prosthesis use and transport, and adjustments of different prostheses to keep up with their child's growth.Clinicians should be aware of the challenges of RSP use to best support children and their families.Designers should focus on addressing limitations with current RSPs to facilitate the diverse needs of pediatric users.

Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI.

The rise of functional magnetic resonance imaging (fMRI) has led to a deeper understanding of cortical processing of pain. Central to these advances has been the identification and analysis of "functional networks", often derived from groups of pre-selected pain regions. In this study our main objective was to identify functional brain networks related to pain perception by examining whole-brain activation, avoiding the need for a priori selection of regions. We applied a data-driven technique-Constrained Principal Component Analysis for fMRI (fMRI-CPCA)-that identifies networks without assuming their anatomical or temporal properties. Open-source fMRI data collected during a thermal pain task (33 healthy participants) were subjected to fMRI-CPCA for network extraction, and networks were associated with pain perception by modelling subjective pain ratings as a function of network activation intensities. Three functional networks emerged: a sensorimotor response network, a salience-mediated attention network, and the default-mode network. Together, these networks constituted a brain state that explained variability in pain perception, both within and between individuals, demonstrating the potential of data-driven, whole-brain functional network techniques for the analysis of pain imaging data.