RESUMO
Behaviour of radionuclides with different distribution types in the organism of animals of various ages was studied. Depending on the age of experimental animals, an essential difference in biokinetic parameters such as coefficients of absorbtion from gastro-intestinal tract, distribution and retention levels in critical organs, retention and excretion rates of radionuclides was found.
Assuntos
Envelhecimento/metabolismo , Radioisótopos/farmacocinética , Administração Oral , Animais , Distribuição de Qui-Quadrado , Injeções Intraperitoneais , Injeções Intravenosas , Absorção Intestinal , Radioisótopos/administração & dosagem , Ratos , Distribuição TecidualRESUMO
The authors provide the data obtained in experimental animals, pertaining to the influence of certain modifying factors on metabolism and biological effects induced by radioactive isotopes of iodine, by transuranium elements and beryllium. Out of all the modifying factors investigated, the form of the introduced compound and age turned out the most significant ones.
Assuntos
Envelhecimento/fisiologia , Radioisótopos/farmacologia , Amerício/farmacocinética , Amerício/farmacologia , Animais , Berílio/farmacocinética , Berílio/farmacologia , Feminino , Radioisótopos do Iodo/farmacocinética , Radioisótopos do Iodo/farmacologia , Plutônio/farmacocinética , Plutônio/farmacologia , Radioisótopos/farmacocinética , RatosRESUMO
In experiments with rats a study was made of the influence of pregnancy and lactation as well as of trivalent and bivalent iron on the resorption of 7BeCl2 from the digestive tract and distribution thereof among organs and tissues.