Effects of Ramipril and Isradipin on hemorheological profiles in patients with arterial hypertension.

In this study, the effect of the angiotensin-converting-enzyme inhibitor (ACE inhibitor) Ramipril (5 mg/day) and calcium antagonist Isradipin (5 mg/day) treatment of two groups of hypertensive patients (n = 22 in each of group) was evaluated. The parameters of the hemorheological profile (blood and plasma viscosity, red blood cell aggregation and deformation, plasma protein concentration and its osmolality, hematocrit and ratio of Hct/blood viscosity) were measured in basal conditions (before treatment) and after 3 weeks of treatment. The patients showed some increased blood, plasma viscosity, RBC aggregability and fibrinogen concentration in basal conditions. In both groups of patients, three main parameters of the hemorheological profile (plasma viscosity, Hct and RBC aggregation) decreased after treatment. No significant changes in red cell deformability was found. In conclusion, ACE inhibition with Ramipril and calcium channel blocking with Isradipin lead to a moderate improvement of blood rheology in patients with hypertension. This may be explained by the pronounced vasodilatatory effect of ACE inhibitor and calcium antagonist, though their acting mechanism is different.

[Hemorheological profiles in patients with arterial hypertension and bronchial asthma]. / Gemoreologicheskie profili u patsientov s arterial'noí gipertenzieí i bronkhial'noí astmoí.

Hemorheological parameters were studied in patients with essential hypertension (men and women) and those with bronchial asthma. The rheological findings were established as a hemorheological profile. The latter is a set of macro- and microrheological parameters under various pathological conditions. The data show that blood viscosity was increased and correlate with blood pressure in hypertensive patients. There were more significant changes in the male populations of the two groups. The main cause of decreased blood fluidity and oxygen transport efficiency under these conditions is associated with hemoconcentration, elevated plasma levels of protein and increased plasma viscosity. The findings suggest that with the concept of a hemorheological profile one can correct rheological disturbances under various clinical conditions.

[Changes in the microcirculation of the pericardium of the dog during adaptation to static muscular loads]. / Izmeneniia mikrotsirkuliatsii perikarda u sobak pri adaptatsii k staticheskim myshechnym nagruzkam.

The data obtained revealed an increase of physiological working ability, economizing of a number of functions on the systemic level as well as morphological parameters of the vascular microregion in the course of training--adaptation to muscular loads in dogs. Apart from that, an increasing permeability for water and protein was maintained due to a beneficial readjustment of the microregion--module communications as well as to augmentation of all the parameters of the metabolic link. Desadaptation led to decreasing physiological working ability and inadequate increase in the circulation and respiration on the level of systemic parameters. On the other hand, the transcapillary exchange of water and protein was significantly decreased with a respective morphological reduction of the pericardium capillaries' metabolic surface.

[Protective effect of a corpuscular polyvalent Pseudomonas aeruginosa vaccine in generalized chronic Pseudomonas aeruginosa infection in mice with cyclophosphamide-induced leukopenia]. / Protektivnyi éffekt korpuskuliarnoi polivalentnoi sinegnoinoi vaktsiny pri generalizovannoi khronicheskoi sinegnoinoi infektsii myshei s leikopeniei, vyzvannoi tsiklofosfamidom.

The prophylactic effect of immunization with P. aeruginosa polyvalent corpuscular vaccine has been shown on the model of P. aeruginosa generalized chronic infection in mice with leukopenia induced by the intraperitoneal injection of cyclophosphamids. This effect is manifested by the increased resistance of the animals to sublethal doses of P. aeruginosa strain, as well as by more intense general and specific immunological responses in the infected animals (the increase of specific antibody titers, the number of leukocytes in the blood serum and the phagocytic activity of the cells of peritoneal exudate).