[The influence of purine nucleotides and adenosine on bioelectrical activity of bat (Pipistrellus nathusii) heart].

The aim of work was to investigate effects of adenosine, AMP, GMP and ADP-ribose on bioelectric activity of bat heart. Purine nucleotides decreased action potential duration at level of 90% (APD90) repolarization in bat ventricular myocardium. When preparation of right ventricle was paced with frequency of 6 Hz, APD50 and APD90 were 7 +/- 2 ms and 60 +/- 5 ms, respectively. Adenosine decreased APD90 by 50 +/- 10% (n=6), AMP - by 30 +/- 10% (n=6), GMP - by 38 +/- 5% (n=6), ADP-ribose - by 24 +/- 6% (n=6) (concentration of all compounds - 10 ). Effects of purine nucleotides and nucleoside in bat ventricular myocardium exceed effects of same compounds in rat and ground squirrel ventricular myocardium. Inhibitory effects of purine nucleotides and adenosine in bat heart could be mediated by A1 adenosine receptors.

[Regulatory issues of biologically active supplements in Armenia]. / Voprosy reguliatsii biologicheski aktivnykh dobavok v Armenii.

Since 1996 by Drug and Medical Technology Agency of the Ministry of Health of the Republic Armenia there has been a record of biologically active supplements, and up to now it numbers 61 products. There has been created a database on biologically active supplements containing relevant information on producers, composition of the product, indications for applying etc. There have been cited some data on examining biologically active supplements and on criteria of such products appraisal. The parameters of not approved Dietary supplements Applications are included and the requirements for Dietary supplements Labels are described in it. There has been cited the division of registration biologically active supplements as per active ingredients and recommendations on use. According to the results of special questionnaire for the Yerevan policlinic doctors, there have been analyzed the spreading area and dynamics biologically active supplements prescription Also there has been estimated the adequacy of their prescription and doctors opinion this product.