[Study of cytokines content and gangliosides metabolism at experimental brain edema].

The content of cytokines, and gangliosides metabolism, and the quantity of lipid peroxidation products were studied at experimental brain edema. Data obtained show increase the level of proinflammatory cytokins and decrease the level of antiinflammatory cytokines during development of brain edema. Along with this we reveal the accumulation of lipid peroxidation products (diene conjugates, hydroperoxides, and malonic dialdehyde). Each fraction of gangliosides decreased, but the product of their hydrolytic dissociation sphingosine increased at experimental brain edema.

[Effect of cysteine lithium salt on lipid peroxidation in the model of dopaminergic system disorder].

The antioxidant activity of a newly synthesized compound, cysteine lithium salt, was discovered using methyl oleate oxidation model of dopaminergic system disorder. Experimental data show that injection of the synthesized compound in animals with experimentally induced L-DOPA brings to normalization effect conditioned by inhibiting free radical reactions in the nuclear and mitochondrial fractions of brain cells. Antioxidant effect of the synthesized compound is related to its chemical structure that contains cysteine--an agent involved in the biosynthesis of glutathione, which is a component of glutathione peroxidase and glutathione reductase enzymes participating in the antiradical protection system.