RESUMO
A controlled clinical trial included 115 patients with meningeal and focal tick-borne encephalitis, 38 of them received nonspecific treatment alone, 77 were given adjuvant intramuscular immunoglobulin against tick-borne encephalitis. The latter are shown to improve much more rapidly than patients treated only symptomatically. When calculating adequate immunoglobulin doses, it is necessary to take in consideration not only the amount of the compound, but also the concentration of the specific antibodies. The authors propose treatment schemes for patients with meningeal and focal tick-borne encephalitis.
Assuntos
Especificidade de Anticorpos , Encefalite Transmitida por Carrapatos/terapia , Imunoglobulinas/administração & dosagem , Doença Aguda , Anticorpos Antivirais/administração & dosagem , Anticorpos Antivirais/imunologia , Relação Dose-Resposta Imunológica , Vírus da Encefalite Transmitidos por Carrapatos/imunologia , Humanos , Imunoglobulinas/imunologia , Injeções Intramusculares , Meningoencefalite/terapia , Indução de Remissão , Fatores de TempoRESUMO
A case of group infection with tick-borne encephalitis (TBE) in Bikin, Khabarovsk Territory is reviewed. The disease developed as a result of drinking raw cow milk, bought from one owner, and eating sour-milk products made of that milk. 5 persons from 3 families were ill, in three cases the outcome was lethal. Data of clinical, epidemiological, viral and serological examinations confirm the diagnosis of TBE. Various antibodies to TBE virus have been determined in the blood of cows. The presence of complement-fixing antibodies may indicate fresh infection. The characteristics of TBE viral strain, isolated from the brain of dead Z. N. F. is presented on white mice. The data obtained confirm the previous suggestion on possible transmission of TBE virus with cow milk.
Assuntos
Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação , Encefalite Transmitida por Carrapatos/transmissão , Leite/microbiologia , Animais , Anticorpos Antivirais/sangue , Antígenos Virais/sangue , Laticínios , Vírus da Encefalite Transmitidos por Carrapatos/imunologia , Encefalite Transmitida por Carrapatos/imunologia , Encefalite Transmitida por Carrapatos/microbiologia , Saúde da Família , Feminino , Microbiologia de Alimentos , Humanos , Masculino , SibériaRESUMO
The natural foci of Lyme's disease with the main vector Ix. persulcatus tick have been detected in Khabarovsk Territory. Five B. burgdorferi strains were isolated from the adult unfed ticks of this species, featuring 20% infection rate in the suburbs of Khabarovsk. A wide spread of the infection in this territory is demonstrated. The authors describe the typical pattern of early stages of serologically documented disease.
