Effect of monochromatic light of low intensity on L929 skin fibroblast culture.

Effects of exposure to low-intensity monochromatic red spectrum radiation in different modes were studied on L929 skin fibroblast culture. Radiometric and cytological study of cell culture before and after irradiation showed that monochromatic low-intensity radiation stimulated skin fibroblasts in L929 culture under certain conditions.

Electromagnetic oscillations as a factor modulating blood neutrophil function.

Effects of various physical factors of electromagnetic nature on the synthetic and phagocytic activities of neutrophils were studied in vitro on the blood of patients with breast cancer. We found that alternating magnetic field, low-intensity laser, photodiod radiation, and their combinations induced mobilization of blood neutrophil function.

[Optimal conditions for producing immunomodulating effect of epithalamine as component of neoadjuvant chemotherapy using autoplasma and autoblood in patients with locally advanced breast cancer]. / Usloviia optimal'noi realizatsii immunomoduliruiushchego deistviia preparata épitalamina u bol'nykh mestorasprostranennym rakom molochnoi zhelezy pri ad''iuvantnoi khimioterapii na estestvennykh sredakh organizma.

Neoadjuvant chemotherapy was given to 105 patients with locally advanced breast cancer after incubation of cytostatics with autoplasma (APCT) and autoblood (AHCT). Most of them also received epithalamine after incubation with AHCT. That significantly improved such parameters of cellular immunity as T-cell content, their subset distribution and function. The most favorable changes were observed when epithalamine was used in conjunction with AHCT. A similar immuno-modulating effect was exerted when epithalamine was used irrespective of either CMAV or CMFV regimens.

[A novel method of drug-free immunocorrection by exposing cancer patients' blood to alternating magnetic field]. / Novyi metod bezmedikamentoznoi immunokorrektsii s pomoshch'iu vozdeistviia peremennym magnitnym polem na autokrov' onkologicheskikh bol'nykh.

The study was concerned with effect of alternating magnetic field (AMF) on immunobiological characteristics of lymphocytes from patients with locally-advanced breast tumors. Patients received infusions of treated autoblood and changes in their immunological status were followed up. Stimulation of T-, B- and NK- cells was observed. Immuno-regulating effect was apparent when autoblood was treated with 50 H/25 mT1 and 100 H/50 mT1.

[Effect of new chemotherapeutic methods on the biologic tissue environment and on the immune status of patients with breast cancer]. / Vliianie novykh metodov khimioterapii na biologicheskikh sredakh organizma na immunnyi status bol'nykh rakom molochnoi zhelezy.

Standard (SCT), autoplasmochemotherapy using cytostatics preincubation with autoplasma (APCT) and autoblood (autohemochemotherapy--AHCT) were compared to evaluate their effects on locally advanced breast tumors. SCT showed marked immunosuppressor effect while APCT and, particularly, AHCT--a sparing one. The use of the latter modalities involved significantly higher levels of active T-, NK- and cytotoxic CD+ 8 cells. A comparison of the latter methods also showed ABCT to yield a better subset balance between T- and B-cells and a higher level of their mitogen response.

[Effect of small doses of ionizing radiation on selected antioxidant and immunologic parameters in patients with cervical cancer]. / Vliianie malykh doz ioniziruiushchego izlucheniia na otdel'nye pokazateli antiokislitel'noi sistemy zashchity organizma i immunnyi status bol'nykh rakom sheiki matki.

We analyzed the indices of antioxidant and immune systems in 69 patients with cervical carcinoma T3NxMo at different stages of radiotherapy. Radiation doses of 10-20 Gy were followed by certain normalization of antioxidant enzyme levels, increased concentrations of vitamins E and A in immunocompetent blood cells and improved the penetration and elastic properties of formed cells. The dosage stimulated the activity of helper-inducing and cytotoxic T-cells. Such effects should be taken into account when working out regimens of complex treatment of locally-advanced cervical carcinoma which include cytostatic drugs and radiation.

[Immunocorrective effect of alternating magnetic field in the postoperative period in malignant bladder cancer]. / Immunokorrigiruiushchee deistvie peremennogo magnitnogo polia v posleoperatsionnom periode pri zlokachestvennykh opukholiakh mochevogo puzyria.

The study deals with immune status of patients operated for bladder cancer and exposed postoperatively to alternating magnetic field (MF) (hypothalamus and operative field). MF application was followed by higher T- and B-lymphocyte and CD4+, CD16+ cell levels as well as enhanced T-cell activity; no postoperative complications were registered and tumor relapse rates were relatively low. The effect was likely to be due to antistressor influence of MF. The procedure may substitute drug therapy for immunocorrection and to avoid recurrence of bladder cancer.

[Effectiveness of immunomodulators in multimodal treatment of patients with lung cancer]. / Effektivnost' immunomoduliatorov pri kompleksnom lechenii bol'nykh rakom legkogo.

The analysis of clinical and immunologic findings indicate that retinol and decaris influence functional activity of immune cells at stage II of lung cancer irrespective of histological structure. In stage III, retinol induced changes in proportion of lymphocyte subpopulations, more evident in glandular cancer. Both immunomodulators lowered the number of purulent complications after surgical interventions. It is only retinol that influenced metastatic dissemination in lung cancer stage II-III.