[The central vascular and metabolic effects of pyroglutamic acid]. / Tsentral'nye sosudistye i metabolicheskie éffekty piroglutaminovoi kisloty.

The ability of pyroglutamic acid, a cyclic glutamic acid derivative, to increase cerebral blood flow, to decrease the resistance of brain vessels, and to relax the isolated grafts of cerebral arteries has been demonstrated. Pyroglutamic acid markedly stimulated brain metabolism: increased glucose uptake and utilization by cerebral tissues and decreased brain lactate dehydrogenase activity.

[Effect of 2-pyrrolidone and gamma-butyrolactone on the rate of 14C-leucine incorporation into the proteins of different brain structures and of their arterial tissues]. / Vliianie pirrolidona-2 i gamma-butirolaktona na skorost' vkliucheniia 14C-leitsina v belki razlichnykh struktur golovnogo mozga i tkanei ego arterii.

The ability of cyclic GABA and GHBA derivatives--2-pyrrolidone and gamma-butyrolactone--to increase markedly the inclusion of 14C-leucine in the proteins of hypothalamus and cerebral arteries both normally and in condition of cerebral blood supply disturbances produced by unilateral 20 min ligation of a common carotid artery has been demonstrated.