RESUMO
Granulomatous inflammation of the pituitary and pituitary abscesses are rare entities. These conditions are found even more rarely in the pediatric aged population. We report a case of a radiographic and clinical, sterile pituitary abscess with non-caseating granulomatous inflammation in a girl who presented with hypopituitarism, meningeal irritation, and symptoms of pituitary apoplexy.
Assuntos
Abscesso/complicações , Granuloma/complicações , Doenças da Hipófise/complicações , Abscesso/diagnóstico por imagem , Adolescente , Ceftriaxona/uso terapêutico , Desamino Arginina Vasopressina/uso terapêutico , Desogestrel/uso terapêutico , Diabetes Insípido/tratamento farmacológico , Diabetes Insípido/etiologia , Etinilestradiol/uso terapêutico , Feminino , Humanos , Hidrocortisona/uso terapêutico , Hipogonadismo/complicações , Hipogonadismo/tratamento farmacológico , Imageamento por Ressonância Magnética , Doenças da Hipófise/diagnóstico por imagem , Tireotropina/sangue , Tiroxina/sangue , Tomografia Computadorizada por Raios XRESUMO
Cells of Cryptococcus neoformans grown on xanthine or urate as the sole sources of nitrogen produced numerous, single membrane-bound organelles, deemed to be microbodies. Electron images of these structures showed positive cytochemical staining for catalase and alpha-hydroxy acid oxidase, known marker enzyme activities for microbodies. Microbodies in xanthine and urate-grown cells were cytochemically reactive for the presence of the hydrogen peroxide-producing xanthine and urate oxidases. Molybdenum and phosphorus (elements associated with the cofactor common to nitrogen scavenging enzymes) were detected in the substrate-induced microbodies by X-ray dispersive microanalysis. The single limiting membrane of the substrate-induced microbody was stained by a modified Gomori reaction for the presence of alkaline phosphatase, thereby suggesting the participation of this enzymic activity in the events associated with microbody chemistry.
